Sulforaphane as an anticancer molecule: Mechanisms of action, synergistic effects, enhancement of drug safety, and delivery systems

MM Kamal, S Akter, CN Lin, S Nazzal - Archives of pharmacal research, 2020 - Springer
Sulforaphane is an isothiocyanate compound that has been derived from cruciferous
vegetables. It was shown in numerous studies to be active against multiple cancer types …

Sulforaphane as a promising molecule for fighting cancer

M Lenzi, C Fimognari, P Hrelia - Advances in nutrition and cancer, 2014 - Springer
Cancer is a complex disease characterized by multiple genetic and molecular alterations
involving transformation, deregulation of apoptosis, proliferation, invasion, angiogenesis …

Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells

L Gamet-Payrastre, P Li, S Lumeau, G Cassar… - Cancer research, 2000 - AACR
Sulforaphane is an isothiocyanate that is present naturally in widely consumed vegetables
and has a particularly high concentration in broccoli. This compound has been shown to …

Multi-targeted prevention of cancer by sulforaphane

JD Clarke, RH Dashwood, E Ho - Cancer letters, 2008 - Elsevier
Isothiocyanates are found in cruciferous vegetables such as broccoli, Brussels sprouts,
cauliflower, and cabbage. Epidemiologic studies suggest that cruciferous vegetable intake …

[HTML][HTML] Sulforaphane and its bifunctional analogs: Synthesis and biological activity

Ł Janczewski - Molecules, 2022 - mdpi.com
For decades, various plants have been studied as sources of biologically active compounds.
Compounds with anticancer and antimicrobial properties are the most frequently desired …

Sulforaphane as a promising natural molecule for cancer prevention and treatment

OA Elkashty, SD Tran - Current Medical Science, 2021 - Springer
Tumorigenicity-inhibiting compounds have been identified in our daily diet. For example,
isothiocyanates (ITCs) found in cruciferous vegetables were reported to have potent cancer …

[HTML][HTML] Sulforaphane potentiates anticancer effects of doxorubicin and cisplatin and mitigates their toxic effects

C Calcabrini, F Maffei, E Turrini… - Frontiers in …, 2020 - frontiersin.org
The success of cancer therapy is often compromised by the narrow therapeutic index of
many anticancer drugs and the occurrence of drug resistance. The association of anticancer …

Discovery and development of sulforaphane as a cancer chemopreventive phytochemical1

Y Zhang, L Tang - Acta Pharmacologica Sinica, 2007 - Wiley Online Library
Sulforaphane (SF) is a phytochemical that displays both anticarcinogenic and anticancer
activity. SF modulates many cancer‐related events, including susceptibility to carcinogens …

Sulforaphane as a potential remedy against cancer: Comprehensive mechanistic review

S Khan, KA Awan, MJ Iqbal - Journal of Food biochemistry, 2022 - Wiley Online Library
Sulforaphane belongs to the active class of isothiocyanates capable of delivering various
biological benefits for health promotion and disease prevention. This compound is …

Chemopreventive activity of sulforaphane

X Jiang, Y Liu, L Ma, R Ji, Y Qu, Y Xin… - … design, development and …, 2018 - Taylor & Francis
Cancer is one of the major causes of morbidity and mortality in the world. Carcinogenesis is
a multistep process induced by genetic and epigenetic changes that disrupt pathways …