Abstract Interleukin-17 (IL-17) is involved in a wide range of inflammatory disorders and in
recruitment of inflammatory cells to injury sites. A recent study of IL-17 knock-out mice …

Cytokines, essential mediators of inflammatory and immune responses, play an important
role in the pathophysiological processes associated with neuropathic pain following …

Pathological pain imposes a huge burden on the economy and the lives of patients. At
present, drugs used for the treatment of pathological pain have only modest efficacy and are …

Abstract Interleukin-17A (IL-17A) is considered an important pro-inflammatory cytokine but
its importance in joint diseases such as rheumatoid arthritis (RA) is unclear. It has also been …

Neuropathic pain seriously affects people's life, but its mechanism is not clear. Interleukin-17
(IL-17) is a proinflammation cytokine and involved in pain regulation. Our previous study …

Chronic pain remains to be a clinical challenge and is recognized as a major health problem
with varying impacts on quality of life. Currently, the first-line therapy for chronic pain is …

Interleukin (IL)-17A, a recently described novel T cell cytokine, orchestrates inflammation in
a variety of immune-mediated diseases. In the present investigation, we analyzed the …

In the present study, we assessed IL-17 levels at 3 and 8 days following various forms of
injuries to the sciatic nerve and related the cytokine levels to the pain behaviors associated …

Immune cells are critical in promoting neuroinflammation and neuropathic pain and in
facilitating pain resolution, depending on their inflammatory and immunoregulatory cytokine …

Immunity and neuroinflammation play major roles in neuropathic pain. Spinal interleukin (IL)-
17A, as a mediator connecting innate and adaptive immunity, has been shown to be an …