Tryptophan metabolism and COVID-19-induced skeletal muscle damage: Is ACE2 a key regulator?

H Takeshita, K Yamamoto - Frontiers in nutrition, 2022 - frontiersin.org
The severity of coronavirus disease 2019 (COVID-19) is characterized by systemic damage
to organs, including skeletal muscle, due to excessive secretion of inflammatory cytokines …

Tryptophan‐Kynurenine Pathway in COVID‐19‐Dependent Musculoskeletal Pathology: A Minireview

S Vyavahare, S Kumar, N Cantu, R Kolhe… - Mediators of …, 2021 - Wiley Online Library
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) causes coronavirus
disease 2019 (COVID‐19), affecting multiple organ systems, including the respiratory tract …

The tryptophan catabolite or kynurenine pathway in COVID-19 and critical COVID-19: a systematic review and meta-analysis

AF Almulla, T Supasitthumrong… - BMC Infectious …, 2022 - Springer
Abstract Background Coronavirus disease 2019 (COVID-19) is accompanied by activated
immune-inflammatory pathways and oxidative stress, which both induce indoleamine-2, 3 …

Altered tryptophan absorption and metabolism could underlie long-term symptoms in survivors of coronavirus disease 2019 (COVID-19)

İ Eroğlu, BÇ Eroğlu, GS Güven - Nutrition, 2021 - Elsevier
The global pandemic of COVID-19 has been lasting for more than one year and there is little
known about the long-term health effects of the disease. Long-COVID is a new term that is …

[HTML][HTML] COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status

T Thomas, D Stefanoni, JA Reisz, T Nemkov… - JCI insight, 2020 - ncbi.nlm.nih.gov
BACKGROUND Reprogramming of host metabolism supports viral pathogenesis by fueling
viral proliferation, by providing, for example, free amino acids and fatty acids as building …

SARS-cov2 infection alters tryptophan catabolism and phospholipid metabolism

G Kaur, X Ji, I Rahman - Metabolites, 2021 - mdpi.com
Coronavirus disease 2019 (COVID-19) has so far infected hundreds of million individuals,
with several million deaths worldwide. The lack of understanding of the disease …

Metabolic reprogramming in SARS-CoV-2 infection impacts the outcome of COVID-19 patients

LE Martínez-Gómez, I Ibarra-González… - Frontiers in …, 2022 - frontiersin.org
Introduction Severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) infection
triggers inflammatory clinical stages that affect the outcome of patients with coronavirus …

Tryptophan catabolites, inflammation, and insulin resistance as determinants of chronic fatigue syndrome and affective symptoms in long COVID

HK Al-Hakeim, A Khairi Abed… - Frontiers in Molecular …, 2023 - frontiersin.org
Critical COVID-19 disease is accompanied by depletion of plasma tryptophan (TRY) and
increases in indoleamine-dioxygenase (IDO)-stimulated production of neuroactive …

Urine Metabolite Analysis to Identify Pathomechanisms of Long COVID: A Pilot Study

M Taenzer, J Löffler-Ragg, A Schroll… - International …, 2023 - journals.sagepub.com
Background: Around 10% of people who had COVID-9 infection suffer from persistent
symptoms such as fatigue, dyspnoea, chest pain, arthralgia/myalgia, sleep disturbances …

[PDF][PDF] The COVID-19 “Bad Tryp” Syndrome: NAD/NADH+, Tryptophan Phenylalanine Metabolism and Thermogenesis like Hecatomb–The Hypothesis of …

Z LGFABD - J Infect Dis Epidemiol, 2022 - researchgate.net
Introduction: There is a significant imbalance in the generation of NAD/NADH+(niacin),
which affects chemical reactions in the intracellular environment in COVID-19 and yellow …