High‐throughput DNA sequencing techniques enable large‐scale measurement of somatic
mutations in tumors. Cancer genomics research aims at identifying all cancer‐related genes …

High-throughput DNA sequencing is revolutionizing the study of cancer and enabling the
measurement of the somatic mutations that drive cancer development. However, the …

Technological advances in next-generation sequencing have uncovered a wide spectrum of
aberrations in cancer genomes. The extreme diversity in cancer mutations necessitates …

Recent genome sequencing studies have shown that the somatic mutations that drive
cancer development are distributed across a large number of genes. This mutational …

Recent genome sequencing studies have shown that the somatic mutations that drive
cancer development are distributed across a large number of genes. This mutational …

Genomic information on tumors from 50 cancer types cataloged by the International Cancer
Genome Consortium (ICGC) shows that only a few well-studied driver genes are frequently …

Distinguishing driver mutations from passenger mutations is critical to the understanding of
the molecular mechanisms of carcinogenesis and for identifying prognostic and diagnostic …

Cancer is often driven by the accumulation of genetic alterations, including single nucleotide
variants, small insertions or deletions, gene fusions, copy-number variations, and large …

A major challenge for distinguishing cancer-causing driver mutations from inconsequential
passenger mutations is the long-tail of infrequently mutated genes in cancer genomes. Here …

Background Cancer sequencing projects are now measuring somatic mutations in large
numbers of cancer genomes. A key challenge in interpreting these data is to distinguish …