The goal of translational medicine is to use an improved understanding of human biology to
develop new clinical approaches. Immune responses are highly variable from one person to …

Highlights•Variation in human immunity is determined both by the proportion of immune cell
subsets and their respective expression profiles.•Single cell technologies can help to …

Humans exhibit considerable variability in their immune responses to the same immune
challenges. Such variation is widespread and affects individual and population‐level …

Abstract The Immune Variation (ImmVar) project is one of a series of recent efforts to map
the extent of variation in immune function in healthy human subjects. The focus of our initial …

Immune responses demonstrate a high level of intra-species variation, compensating for the
specialization capacity of pathogens. The recent advent of in-depth immune phenotyping …

The human immune system presents remarkable inter-individual variability in response to
pathogens or perturbations. Recent high-throughput technologies have enabled the …

Immune responses in human populations are highly variable, with this variability presenting
challenges for vaccine design. As such a better understanding of the factors that determine …

Humans display remarkable immune response variation when exposed to identical immune
challenges. However, our understanding of the genetic, evolutionary, and environmental …

Studying the human immune system is challenging. These challenges stem from the
complexity of the immune system itself, the heterogeneity of the immune system between …

The human immune system is highly variable between individuals but relatively stable over
time within a given person. Recent conceptual and technological advances have enabled …