Erythropoietin improves left ventricular function and coronary flow in an experimental model of ischemia‐reperfusion injury

P van der Meer, E Lipsic, RH Henning… - European Journal of …, 2004 - Wiley Online Library
Background: Recent studies show that erythropoietin (EPO) plays a protective role in brain
ischemia. In this condition, administration of EPO protects neurons from ischemic damage …

Erythropoietin protects the myocardium against reperfusion injury in vitro and in vivo

AJ Bullard, P Govewalla, DM Yellon - Basic research in cardiology, 2005 - Springer
Objective Erythropoietin (EPO) is a hormone that is currently used to treat patients with renal
failure and anaemia. However, it has also been shown to protect against …

Recombinant human erythropoietin protects the myocardium from ischemia-reperfusion injury and promotes beneficial remodeling

L Calvillo, R Latini, J Kajstura, A Leri… - Proceedings of the …, 2003 - National Acad Sciences
Erythropoietin (EPO), originally identified for its critical hormonal role in promoting
erythrocyte survival and differentiation, is a member of the large and diverse cytokine …

Timing of erythropoietin treatment for cardioprotection in ischemia/reperfusion

E Lipšic, P van der Meer, RH Henning… - Journal of …, 2004 - journals.lww.com
Erythropoietin (EPO) is a hormone known to stimulate hematopoiesis. However, recent
research suggests additional properties of EPO, such as protection against …

Administration of erythropoietin fails to improve long-term healing or cardiac function after myocardial infarction in the rat

SL Hale, C Sesti, RA Kloner - Journal of cardiovascular …, 2005 - journals.lww.com
Erythropoietin (epo), initially recognized and used clinically to increase erythropoiesis, has
been shown to have beneficial effects on various other tissues in the setting of hypoxia and …

Erythropoietin induces neovascularization and improves cardiac function in rats with heart failure after myocardial infarction

P Van Der Meer, E Lipsic, RH Henning… - Journal of the American …, 2005 - jacc.org
Objectives: We assessed the effects of erythropoietin (EPO) treatment in a rat model of post-
myocardial infarction (MI) heart failure. Background: Erythropoietin, traditionally known as a …

Protective effects of erythropoietin in cardiac ischemia: from bench to bedside

E Lipšic, RG Schoemaker, P van der Meer… - Journal of the American …, 2006 - jacc.org
Erythropoietin (EPO) is a hypoxia-induced hormone produced in the kidneys that stimulates
hematopoiesis in the bone marrow. However, recent studies have also shown important …

Erythropoietin attenuates the tissue injury associated with hemorrhagic shock and myocardial ischemia

M Abdelrahman, EJ Sharples, MC McDonald, M Collin… - Shock, 2004 - journals.lww.com
Here we investigate the effects of erythropoietin (EPO) on the tissue/organ injury caused by
hemorrhagic shock (HS), endotoxic shock, and regional myocardial ischemia and …

Mechanisms of erythropoietin‐mediated cardioprotection during ischemia‐reperfusion injury: role of protein kinase C and phosphatidylinositol 3‐kinase signaling

PR Hanlon, P Fu, GL Wright, C Steenbergen… - The FASEB …, 2005 - Wiley Online Library
Langendorff‐perfused rat hearts treated with EPO exhibited significantly improved
postischemic recovery of left ventricular developed pressure (LVDP) and reduced infarct …

An update on the cardiac effects of erythropoietin cardioprotection by erythropoietin and the lessons learnt from studies in neuroprotection

MA Bogoyevitch - Cardiovascular research, 2004 - academic.oup.com
Erythropoietin (Epo) was once thought to act exclusively in the formation of red blood cells.
As recently reviewed by Smith et al.[Cardiovasc. Res. 59 (2003) 538–548], Epo can also act …