Roles for long non-coding RNAs in physiology and disease

MT Melissari, P Grote - Pflügers Archiv-European Journal of Physiology, 2016 - Springer
While the vast majority of the genome is transcribed into RNA, only a small fraction of these
transcripts have protein-coding potential. A large fraction of the transcribed RNA belongs to …

[HTML][HTML] Long non-coding RNA in neuronal development and neurological disorders

L Li, Y Zhuang, X Zhao, X Li - Frontiers in genetics, 2019 - frontiersin.org
Long non-coding RNAs (lncRNAs) are transcripts which are usually more than 200 nt in
length, and which do not have the protein-coding capacity. LncRNAs can be categorized …

Post-transcriptional regulation of long noncoding RNAs in cancer

X Shi, M Sun, Y Wu, Y Yao, H Liu, G Wu, D Yuan… - Tumor Biology, 2015 - Springer
It is a great surprise that the genomes of mammals and other eukaryotes harbor many
thousands of long noncoding RNAs (lncRNAs). Although these long noncoding transcripts …

lncRNome: a comprehensive knowledgebase of human long noncoding RNAs

D Bhartiya, K Pal, S Ghosh, S Kapoor, S Jalali… - Database, 2013 - academic.oup.com
The advent of high-throughput genome scale technologies has enabled us to unravel a
large amount of the previously unknown transcriptionally active regions of the genome …

[HTML][HTML] The state of long non-coding RNA biology

JS Mattick - Non-coding RNA, 2018 - mdpi.com
Transcriptomic studies have demonstrated that the vast majority of the genomes of mammals
and other complex organisms is expressed in highly dynamic and cell-specific patterns to …

MacroRNA underdogs in a microRNA world: evolutionary, regulatory, and biomedical significance of mammalian long non-protein-coding RNA

L Lipovich, R Johnson, CY Lin - Biochimica et Biophysica Acta (BBA)-Gene …, 2010 - Elsevier
The central dogma of molecular biology relegates RNAs to the role of “messengers” of
genetic information, with proteins as the end products that perform key roles as regulators …

[HTML][HTML] The role of long noncoding RNAs in central nervous system and neurodegenerative diseases

CW Wei, T Luo, SS Zou, AS Wu - Frontiers in behavioral neuroscience, 2018 - frontiersin.org
Long noncoding RNAs (lncRNAs) refer to a group of noncoding RNAs (ncRNAs) that has a
transcript of more than 200 nucleotides in length in eukaryotic cells. The lncRNAs regulate …

Long non‐coding RNAs in cancer: another layer of complexity

JC de Oliveira, LC Oliveira, C Mathias… - The journal of gene …, 2019 - Wiley Online Library
We review the most well characterized long non‐coding RNAs (lncRNAs) with important
roles in hallmarks of cancer, additionally including lncRNAs with a higher potential for …

Emerging epigenetic mechanisms of long non-coding RNAs

K Schaukowitch, TK Kim - Neuroscience, 2014 - Elsevier
Long non-coding RNAs (lncRNAs) have been increasingly appreciated as an integral
component of gene regulatory networks. Genome-wide features of their origin and …

[PDF][PDF] Integrated lncRNA function upon genomic and epigenomic regulation

AB Herman, D Tsitsipatis, M Gorospe - Molecular Cell, 2022 - cell.com
Although some long noncoding (lnc) RNAs are known since the 1950s, the past 25 years
have uncovered myriad lncRNAs with diverse sequences, structures, and functions. The …