More than 50 years of efforts to identify the major cytokine responsible for red blood cell
(RBC) production (erythropoiesis) led to the identification of erythropoietin (EPO) in 1977 …

Erythropoietin (EPO) is the crucial cytokine regulator of red blood-cell production. Since the
discovery of EPO in 1985 and the isolation of its cognate receptor four years later, there has …

Committed erythroid progenitor cells require exposure to erythropoietin (Epo) for their
survival and for their quantitatively regulated transition to red blood cells. With regard to Epo …

As essential mediators of red cell production, erythropoietin (EPO) and its cell surface
receptor (EPO receptor [EPOR]) have been intensely studied. Early investigations defined …

A greatly expanded understanding of the biology of endogenous erythropoietin (EPO) has
emerged since the early 1990s. Originally viewed as the renal hormone dedicated to …

Since the isolation and purification of erythropoietin (EPO) in 1977, the essential role of EPO
for mature red blood cell production has been well established. The cloning of the EPO gene …

Erythropoietin (EPO), a humoral regulator of erythropoiesis and replacement therapy for
selected red blood cell disorders in EPO-deficient patients, has been implicated in a wide …

Erythropoietin (EPO) is a glycoprotein that is mainly produced in the adult kidney, and it was
initially highlighted for its action on the hematopoietic system. Moreover, EPO is also …

This minireview is an update of a 1997 review on erythropoletin (EPO) in this journal (1).
EPO is a 30,400-dalton glycoprotein that regulates red cell production. In the human, EPO is …

Summary As Current Opinion, this monograph seeks to summarize, and provoke, new
EPO/EPOR action concepts. Specific problems addressed include: beyond (and before) …