In recent years, the functional interplay between drug-metabolizing enzymes (DMEs) and
drug transporters (DTs) in drug absorption and disposition, as well as the complex drug …

Drug-metabolizing enzymes and transporters (DMETs) are key regulators of the
pharmacokinetics, efficacy, and toxicity of therapeutics. Over the past two decades …

Introduction: Transporters and enzymes play an important role in absorption, distribution,
clearance and elimination of drugs. Areas covered: This review provides an overview of the …

Both metabolizing enzymes and drug transporters play important roles in modulating drug
absorption, distribution, metabolism and elimination. Acting alone or in concert with each …

Germination of the thought of “Enzyme-and Transporter-Based Drug–Drug Interactions:
Progress and Future Challenges” proceedings came about as part of the annual meeting of …

The pharmacokinetics of a drug is dependent upon the coordinate work of influx
transporters, enzymes and efflux transporters (ie, transporter-enzyme interplay). The …

Drug-drug interactions DDI comprise a significant cause of morbidity and mortality
worldwide as they may lead to adverse clinical events, result in decrease/inactivation of the …

Drug–drug interactions mediated by transporters are a serious clinical concern hence a
tremendous amount of work has been done on the characterization of the transporter …

Membrane transporters play diverse roles in the pharmacokinetics and pharmacodynamics
of small‐molecule drugs. Understanding the mechanisms of drug‐transporter interactions at …

Understanding of the interdependence of cytochrome P450 enzymes and P-glycoprotein in
disposition of drugs (also termed “transport–metabolism interplay”) has been significantly …