Efficient synthesis of tetrahydronaphthalene-or isochroman-fused spirooxindoles using tandem reactions

B Wang, HJ Leng, XY Yang, B Han, CL Rao, L Liu… - RSC …, 2015 - pubs.rsc.org
The flexible and simple cascade reaction involving a Michael–aldol or vinylogous Henry-
acetalization relay is described. We have used the cascade reaction to assemble …

Diastereoselective ABB′ three-component synthesis of highly functionalized spirooxindoles bearing five consecutive asymmetric carbons

T Vivekanand, BS Vachan… - The Journal of …, 2019 - ACS Publications
The synthesis of spirooxindoles bearing tetrahydro-4 H-cyclopenta [b] furan framework was
established starting from isatin-derived aldehydes and 2 equiv of 1, 3-dicarbonyl …

Asymmetric Synthesis of Cyclohexane‐Fused Drug‐Like Spirocyclic Scaffolds Containing Six Contiguous Stereogenic Centers via Organocatalytic Cascade …

B Han, W Huang, W Ren, G He… - Advanced Synthesis & …, 2015 - Wiley Online Library
Drug‐like spirocyclic scaffolds have been prepared asymmetrically by fusing fully
functionalized cyclohexanes with medicinally important pyrazolone, rhodanine, barbituric …

Divergent syntheses of spirooxindoles from oxindole-embedded four-membered synthon via cycloaddition reactions

H Shi, L Wang, SS Li, Y Liu, L Xu - Organic Chemistry Frontiers, 2020 - pubs.rsc.org
The highly efficient construction of five and six membered heterocycle fused spirooxindoles
was achieved via the [4+ 1] and formal [4+ 2] cycloaddition reactions between our rationally …

Organocatalytic asymmetric assembly reactions: synthesis of spirooxindoles via organocascade strategies

D Cheng, Y Ishihara, B Tan, CF Barbas III - Acs Catalysis, 2014 - ACS Publications
Spirooxindoles have become a privileged skeleton given their broad and promising
activities in various therapeutic areas. The strategies and catalyst systems described here …

One-pot access to a library of dispiro oxindole-pyrrolidine/pyrrolothiazole-thiochromane hybrids via three-component 1, 3-dipolar cycloaddition reactions

G Uma Rani, S Vivek Kumar, C Bharkavi… - ACS Combinatorial …, 2016 - ACS Publications
A library of novel dispiro compounds containing oxindole pyrrolidine/oxindolopyrrolothiazole-
thiochroman-4-one hybrid frameworks has been synthesized in a fully regio-and …

Dynamic stereoselective annulation via aldol-oxa-cyclization cascade reaction to afford spirooxindole pyran polycycles

M Sohail, F Tanaka - Communications Chemistry, 2019 - nature.com
Spiro polycyclic compounds bearing pyran ring systems are found in bioactive molecules,
and we recently reported the construction of spirooxindole all-carbon polycycles. Here we …

Phosphine-catalyzed Rauhut-Currier domino reaction: a facile strategy for the construction of carbocyclic spirooxindoles skeletons.

C Hu, Q Zhang, Y Huang - Chemistry-An Asian Journal, 2013 - search.ebscohost.com
Push‐over: A novel domino reaction of activated conjugated dienes and
methyleneindolinones incorporates a phosphine‐catalyzed intermolecular Rauhut–Currier …

An unexpected cascade reaction of 3-hydroxyoxindoles with coumarin-3-carboxylates to construct 2, 3-dihydrobenzofuran spirooxindoles

K Zhang, H Han, L Wang, Z Zhang, Q Wang… - Chemical …, 2019 - pubs.rsc.org
An unexpected Michael addition-inspired ring-opening/closure cascade reaction of 3-
hydroxyoxindoles with coumarin-3-carboxylates was developed to access new …

Assembly of spirooxindole derivatives containing four consecutive stereocenters via organocatalytic Michael–Henry cascade reactions

K Albertshofer, B Tan, CF Barbas III - Organic letters, 2012 - ACS Publications
A novel organocatalytic strategy for the synthesis of highly substituted
spirocyclopentaneoxindoles was developed employing simple nitrostyrenes and 3 …