Initiation of the hypothalamic–pituitary–gonadal axis in young girls undergoing central precocious puberty exerts remodeling effects on the prefrontal cortex

D Yang, W Zhang, Y Zhu, P Liu, B Tao, Y Fu… - Frontiers in …, 2019 - frontiersin.org
Central precocious puberty (CPP) has been shown to exert significant effects on
psychosocial development. These early puberty-related hormones and psychosocial …

Frequency-dependent alterations in regional homogeneity associated with puberty hormones in girls with central precocious puberty: A resting-state fMRI study

W Yu, Y Lu, T Chen, Y Xia, J Tang, NM Hussein… - Journal of Affective …, 2023 - Elsevier
Objective Central precocious puberty (CPP) patients are at significantly higher risk of
emotional, mental, and behavioral disorders than those normal pubertal population …

Altered brain structure and functional connectivity associated with pubertal hormones in girls with precocious puberty

T Chen, Y Lu, Y Wang, A Guo, X Xie, Y Fu… - Neural …, 2019 - Wiley Online Library
Pubertal hormones play an important role in brain and psychosocial development. However,
the role of abnormal HPG axis states in altering brain function and structure remains unclear …

Brain structure alterations in girls with central precocious puberty

S Yoshii, T Takatani, T Shiohama, R Takatani… - Frontiers in …, 2023 - frontiersin.org
Purpose Central precocious puberty (CPP) is puberty that occurs at an unusually early age
with several negative psychological outcomes. There is a paucity of data on the …

Cognitive, emotional, and psychosocial functioning of girls treated with pharmacological puberty blockage for idiopathic central precocious puberty

S Wojniusz, N Callens, S Sütterlin… - Frontiers in …, 2016 - frontiersin.org
Central precocious puberty (CPP) develops due to premature activation of the hypothalamic-
pituitary-gonadal (HPG) axis, resulting in early pubertal changes and rapid bone maturation …

Influence of the hypothalamus–pituitary–gonadal axis reactivation and corresponding surging sex hormones on the amplitude of low-frequency oscillations in early …

X Xie, P Liu, T Chen, Y Wang, X Liu, P Ye… - Journal of Affective …, 2019 - Elsevier
Background There has been a myriad of neuroimaging studies that have suggested that
pubertal stages and sex steroid fluctuations contribute to pubertal brain maturation …

The role of puberty in human adolescent brain development

AL Goddings - Brain crosstalk in puberty and adolescence, 2014 - Springer
Many of the physical, social and behavioural changes associated with adolescence are
linked with puberty, the physiological process resulting in reproductive competence. Recent …

Effects of the COVID-19 pandemic on the incidence of central precocious puberty; a narrative review

RB Hoskyns, SR Howard - Journal of Pediatric Endocrinology and …, 2024 - degruyter.com
Central precocious puberty (CPP) is the premature activation of the hypothalamus–pituitary–
gonadal axis, resulting in the early development of secondary sexual characteristics. CPP …

Longitudinal pattern of early maturation on morning cortisol and depressive symptoms: Sex-specific effects

Y Sun, Y Liu, S Yan, J Hu, G Xu, J Liu, FB Tao - Psychoneuroendocrinology, 2016 - Elsevier
There is still insufficient understanding of the underlying processes that contribute to
internalizing problems of early maturing adolescents. The purpose of this study is to …

Attenuated hypothalamic–pituitary–adrenal axis functioning predicts accelerated pubertal development in girls 1 year later

DE Saxbe, S Negriff, EJ Susman… - Development and …, 2015 - cambridge.org
Accelerated pubertal development has been linked to adverse early environments and may
heighten subsequent mental and physical health risks. Hypothalamic–pituitary–adrenal axis …