Olfactory dysfunction in COVID-19: new insights into the underlying mechanisms

R Butowt, K Bilinska, CS von Bartheld - Trends in neurosciences, 2023 - cell.com
The mechanisms of olfactory dysfunction in COVID-19 are still unclear. In this review, we
examine potential mechanisms that may explain why the sense of smell is lost or altered …

COVID-19 and olfactory dysfunction: a looming wave of dementia?

LM Kay - Journal of Neurophysiology, 2022 - journals.physiology.org
Olfactory dysfunction is a hallmark symptom of COVID-19 disease resulting from the SARS-
CoV-2 virus. The cause of the sudden and usually temporary anosmia that most people …

Olfactory dysfunction in COVID-19: pathology and long-term implications for brain health

RL Doty - Trends in Molecular Medicine, 2022 - cell.com
Decreased smell function is related to brain health, future mortality, and quality of life. Most
people inflicted with the SARS-CoV-2 virus evidence some measurable smell dysfunction …

Mechanisms of SARS-CoV-2-associated anosmia

T Tsukahara, DH Brann, SR Datta - Physiological Reviews, 2023 - journals.physiology.org
Anosmia, the loss of the sense of smell, is one of the main neurological manifestations of
COVID-19. Although the SARS-CoV-2 virus targets the nasal olfactory epithelium, current …

Viral infection and smell loss: The case of COVID‐19

I Glezer, A Bruni‐Cardoso… - Journal of …, 2021 - Wiley Online Library
Olfactory disorders have been increasingly reported in individuals infected with SARS‐CoV‐
2, the virus causing the coronavirus disease 2019 (COVID‐19). Losing the sense of smell …

Persistent post–COVID-19 smell loss is associated with immune cell infiltration and altered gene expression in olfactory epithelium

JB Finlay, DH Brann, R Abi Hachem, DW Jang… - Science translational …, 2022 - science.org
SARS-CoV-2 causes profound changes in the sense of smell, including total smell loss.
Although these alterations are often transient, many patients with COVID-19 exhibit olfactory …

Pathophysiological relationship between COVID-19 and olfactory dysfunction: A systematic review

MH Las Casas Lima, ALB Cavalcante… - Brazilian Journal of …, 2022 - SciELO Brasil
Introduction SARS-CoV-2 is the pathogen of COVID-19. The virus is composed of the spike,
membrane and envelope. On physiological smell, odoriferous substances bind to proteins …

Anosmia in COVID-19: a bumpy road to establishing a cellular mechanism

K Bilinska, R Butowt - ACS chemical neuroscience, 2020 - ACS Publications
It has become clear since the pandemic broke out that SARS-CoV-2 virus causes reduction
of smell and taste in a significant fraction of COVID-19 patients. The olfactory dysfunction …

Anosmia in COVID-19: underlying mechanisms and assessment of an olfactory route to brain infection

R Butowt, CS von Bartheld - The Neuroscientist, 2021 - journals.sagepub.com
In recent months it has emerged that the novel coronavirus—responsible for the COVID-19
pandemic—causes reduction of smell and taste in a large fraction of patients. The …

COVID-19–related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters

GD De Melo, F Lazarini, S Levallois… - Science translational …, 2021 - science.org
Whereas recent investigations have revealed viral, inflammatory, and vascular factors
involved in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lung …