Prostate cancer (PCa) is one of the most frequently diagnosed cancers in developed
countries. Several studies suggest that variations in calcium homeostasis are involved in …

Abstract Transient Receptor Potential Melastatin 4 (TRPM4) is a Ca2+‐activated and voltage‐
dependent monovalent cation channel, which depolarizes the plasma cell membrane …

Transient receptor potential melastatin 4 (TRPM4) is a broadly expressed Ca 2+ activated
monovalent cation channel that contributes to the pathophysiology of several diseases. For …

In the fight against prostate cancer (PCa), TRPM8 is one of the most promising clinical
targets. Indeed, several studies have highlighted that TRPM8 involvement is key in PCa …

Although the transient receptor potential melastatin 8 (TRPM8) cold receptor is highly
expressed in prostate cancer (PCa) and constitutes a promising diagnostic and prognostic …

Impaired Ca 2+ signaling in prostate cancer contributes to several cancer hallmarks, such as
enhanced proliferation and migration and a decreased ability to induce apoptosis. Na+ …

In prostate carcinogenesis, androgens are known to control the expression of the transient
receptor potential melastatin 8 (TRPM8) protein via activation of androgen receptor (AR) …

Transient receptor potential melastatin 8 (TRPM8) is a calcium ion-permeable cation
channel that is used as a prognostic marker and therapeutic target for different tumor types …

During the past 5 years it has emerged that the transient receptor potential (TRP) family of
Ca 2+-and Na+-permeable channels plays a diverse and important role in cell biology and …

Transient receptor potential melastatin-8 (TRPM8) represents an emerging target in prostate
cancer, although its mechanism of action remains unclear. Here, we have characterized and …