METHODS Sera were collected from 196 pediatric CD cases and tested for immune
responses: anti-I2, anti-outer membrane protein C (anti-OmpC), anti-CBir1 flagellin (anti …

BACKGROUND & AIMS: The ability to identify children with CD who are at highest risk for
rapid progression from uncomplicated to complicated phenotypes would be invaluable in …

Background Crohn's disease (CD) is often associated with antibodies to microbial antigens.
Differences in immune response may offer clues to the pathogenesis of the disease. The aim …

Background & Aims: The utility of serial measurements of anti-Saccharomyces cerevisiae
(ASCA) and perinuclear antineutrophil cytoplasmic (p-ANCA) antibodies in Crohn's disease …

Background & Aims: The Pediatric Crohn's Disease Activity Index (PCDAI) is a multi-item
measure that, in contrast to the adult-derived CDAI, includes linear growth and places less …

Methods: Data were derived from a prospective database of newly diagnosed children with
inflammatory bowel disease established in 2002 at 18 pediatric gastroenterology centers in …

ABSTRACT Background/Aims Despite documented feasibility, reliability, and validity, the
Pediatric Crohn's Disease Activity Index (PCDAI) has yet to be demonstrated to be sensitive …

Background & Aims Standard therapy for children newly diagnosed with Crohn's disease
(CD) includes early administration of immunomodulators after initial treatment with …

Background Robust evaluation of induction therapies using both clinical and inflammatory
outcomes in pediatric Crohn's disease (CD) are sparse. We attempted to evaluate clinical …

BACKGROUND The relationship between the age at diagnosis and disease course is poorly
defined in children with Crohn's disease (CD). We examined the presentation and course of …