Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors and they serve to be a promising therapeutic target for several neurodegenerative disorders, which includes …
JM Zolezzi, MJ Santos, S Bastías‐Candia… - Biological …, 2017 - Wiley Online Library
Over 25 years have passed since peroxisome proliferators‐activated receptors (PPARs), were first described. Like other members of the nuclear receptors superfamily, PPARs have …
AR Carta - Current drug targets, 2013 - ingentaconnect.com
Parkinson's disease (PD) is amongst the most frequent neurodegenerative disorders, the main pathologic hallmark of which is the degeneration of the substantia nigra pars …
RL Hunter, G Bing - Current neuropharmacology, 2007 - ingentaconnect.com
Evidence suggests inflammation, mitochondria dysfunction, and oxidative stress play major roles in Parkinson's disease (PD), where the primary pathology is the significant loss of …
T Behl, P Madaan, A Sehgal, S Singh… - International Journal of …, 2021 - mdpi.com
One of the utmost frequently emerging neurodegenerative diseases, Parkinson's disease (PD) must be comprehended through the forfeit of dopamine (DA)-generating nerve cells in …
There is increasing evidence for the involvement of mitochondrial dysfunction and oxidative stress in the pathogenesis of many of the major neurodegenerative and neuroinflammatory …
As the growth of the aging population continues to accelerate globally, increased prevalence of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's …
Peroxisome proliferator-activated receptor gamma (PPARgamma) has already been considered as an attractive therapeutic target for the treatment of metabolic disorders …
The peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated transcriptional factor that belongs to the nuclear hormone receptor superfamily. PPARγ was …