PPAR: a therapeutic target in Parkinson's disease

RK Chaturvedi, MF Beal - Journal of neurochemistry, 2008 - Wiley Online Library
Parkinson's disease (PD) is a progressive and chronic neurodegenerative disorder,
characterized by progressive loss of dopaminergic neurons in substantia nigra. The etiology …

Peroxisome proliferator-activated receptors (PPARs) as therapeutic target in neurodegenerative disorders

S Agarwal, A Yadav, RK Chaturvedi - Biochemical and biophysical …, 2017 - Elsevier
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors and they serve to
be a promising therapeutic target for several neurodegenerative disorders, which includes …

PPARs in the central nervous system: roles in neurodegeneration and neuroinflammation

JM Zolezzi, MJ Santos, S Bastías‐Candia… - Biological …, 2017 - Wiley Online Library
Over 25 years have passed since peroxisome proliferators‐activated receptors (PPARs),
were first described. Like other members of the nuclear receptors superfamily, PPARs have …

PPAR-γ: therapeutic prospects in Parkinson's disease

AR Carta - Current drug targets, 2013 - ingentaconnect.com
Parkinson's disease (PD) is amongst the most frequent neurodegenerative disorders, the
main pathologic hallmark of which is the degeneration of the substantia nigra pars …

Agonism of peroxisome proliferator receptor-gamma may have therapeutic potential for neuroinflammation and Parkinson's disease

RL Hunter, G Bing - Current neuropharmacology, 2007 - ingentaconnect.com
Evidence suggests inflammation, mitochondria dysfunction, and oxidative stress play major
roles in Parkinson's disease (PD), where the primary pathology is the significant loss of …

Elucidating the neuroprotective role of PPARs in Parkinson's disease: a neoteric and prospective target

T Behl, P Madaan, A Sehgal, S Singh… - International Journal of …, 2021 - mdpi.com
One of the utmost frequently emerging neurodegenerative diseases, Parkinson's disease
(PD) must be comprehended through the forfeit of dopamine (DA)-generating nerve cells in …

[HTML][HTML] PPARγ as a therapeutic target to rescue mitochondrial function in neurological disease

JC Corona, MR Duchen - Free Radical Biology and Medicine, 2016 - Elsevier
There is increasing evidence for the involvement of mitochondrial dysfunction and oxidative
stress in the pathogenesis of many of the major neurodegenerative and neuroinflammatory …

Peroxisome proliferator-activated receptor gamma (PPAR-γ) and neurodegenerative disorders

YC Chen, JS Wu, HD Tsai, CY Huang, JJ Chen… - Molecular …, 2012 - Springer
As the growth of the aging population continues to accelerate globally, increased
prevalence of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's …

Peroxisome proliferator-activated receptor gamma agonists as neuroprotective agents.

RK Kaundal, SS Sharma - Drug news & perspectives, 2010 - europepmc.org
Peroxisome proliferator-activated receptor gamma (PPARgamma) has already been
considered as an attractive therapeutic target for the treatment of metabolic disorders …

PPARγ and PGC-1α as therapeutic targets in Parkinson's

JC Corona, MR Duchen - Neurochemical research, 2015 - Springer
The peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated
transcriptional factor that belongs to the nuclear hormone receptor superfamily. PPARγ was …