Protective effects of erythropoietin in cardiac ischemia: from bench to bedside

E Lipšic, RG Schoemaker, P van der Meer… - Journal of the American …, 2006 - jacc.org
Erythropoietin (EPO) is a hypoxia-induced hormone produced in the kidneys that stimulates
hematopoiesis in the bone marrow. However, recent studies have also shown important …

A nonerythropoietic derivative of erythropoietin protects the myocardium from ischemia–reperfusion injury

F Fiordaliso, S Chimenti… - Proceedings of the …, 2005 - National Acad Sciences
The cytokine erythropoietin (EPO) protects the heart from ischemic injury, in part by
preventing apoptosis. However, EPO administration can also raise the hemoglobin …

Beyond erythropoiesis: the anti-inflammatory effects of erythropoietin

Q Feng - Cardiovascular research, 2006 - academic.oup.com
Erythropoietin (EPO) is a 30.4-kDa glycoprotein essential for red blood cell production. In
adults, EPO is produced primarily in the kidney via an oxygen-sensing mechanism and …

Recombinant human erythropoietin protects the myocardium from ischemia-reperfusion injury and promotes beneficial remodeling

L Calvillo, R Latini, J Kajstura, A Leri… - Proceedings of the …, 2003 - National Acad Sciences
Erythropoietin (EPO), originally identified for its critical hormonal role in promoting
erythrocyte survival and differentiation, is a member of the large and diverse cytokine …

Timing of erythropoietin treatment for cardioprotection in ischemia/reperfusion

E Lipšic, P van der Meer, RH Henning… - Journal of …, 2004 - journals.lww.com
Erythropoietin (EPO) is a hormone known to stimulate hematopoiesis. However, recent
research suggests additional properties of EPO, such as protection against …

An update on the cardiac effects of erythropoietin cardioprotection by erythropoietin and the lessons learnt from studies in neuroprotection

MA Bogoyevitch - Cardiovascular research, 2004 - academic.oup.com
Erythropoietin (Epo) was once thought to act exclusively in the formation of red blood cells.
As recently reviewed by Smith et al.[Cardiovasc. Res. 59 (2003) 538–548], Epo can also act …

Erythropoietin and the heart: physiological effects and the therapeutic perspective

F Sanchis-Gomar, JL Garcia-Gimenez… - International journal of …, 2014 - Elsevier
Erythropoietin (Epo) has been thought to act exclusively on erythroid progenitor cells. The
identification of Epo receptor (EpoR) in non-haematopoietic cells and tissues including …

Effects of erythropoietin after an acute myocardial infarction: rationale and study design of a prospective, randomized, clinical trial (HEBE III)

AM Belonje, AA Voors, WH van Gilst, SD Anker… - American Heart …, 2008 - Elsevier
BACKGROUND: Preclinical studies have consistently shown that erythropoietin (EPO),
administered after an acute myocardial infarction (AMI), reduces infarct size and improves …

Erythropoietin and treatment of non-anemic conditions—cardiovascular protection

D Fliser, H Haller - Seminars in hematology, 2007 - Elsevier
The well-established physiological function of erythropoietin (EPO) is the induction of
erythropoiesis. A growing body of evidence indicates that EPO has tissue-protective effects …

Acute erythropoietin cardioprotection is mediated by endothelial response

R Teng, JW Calvert, N Sibmooh, B Piknova… - Basic research in …, 2011 - Springer
Increasing evidence indicates that high levels of serum erythropoietin (Epo) can lessen
ischemia–reperfusion injury in the heart and multiple cardiac cell types have been …