Background: The increasing prevalence of antimicrobial resistance, together with the lack of
novel treatment options, negatively affects successful eradication of Helicobacter pylori. The …

BACKGROUND The drug resistance rate of clinical Helicobacter pylori (H. pylori) isolates
has increased. However, the mechanism of drug resistance remains unclear. In this study …

For a long time Helicobacter pylori infections have been treated using the macrolide
antibiotic, clarithromycin. Clarithromycin resistance is increasing worldwide and is the most …

Objectives Resistance to clarithromycin is the most important factor causing failure of
Helicobacter pylori eradication. Although clarithromycin resistance is mainly associated with …

Introduction Primary clarithromycin resistance is increasing worldwide, and it has been
regarded as the main factor reducing the efficacy of Helicobacter pylori therapy. However …

Background and objectives Peptic ulcer disease, chronic gastritis, and stomach cancer are
all caused by H. pylori. The most notable drug for the treatment is the antibiotic …

Background Clarithromycin therapy is effective in eradicating Helicobacter pylori. However,
the resistance of H. pylori to clarithromycin is increasingly reported. The present study aimed …

Purpose. We aimed to investigate the presence of three recently identified point mutations
(A2115G, G2141A and A2144T) of the 23 S rRNA gene and compare them with the three …

Abstract Background Resistance of Helicobacter pylori to clarithromycin has been
associated with A2142G and A2143G point mutations in the 23S rRNA gene. Thus, the …

Antibiotic resistance has brought into question the efficiency of clarithromycin which is a vital
component of eradication therapy for Helicobacter pylori infection. The point mutations …