Helicobacter pylori is a gastric pathogen that causes several gastroduodenal disorders such
as peptic ulcer disease and gastric cancer. Eradication efforts of H. pylori are often …

Objectives: We evaluated a new approach for the rapid detection of clarithromycin
resistance in Helicobacter pylori, based on PCR and denaturing HPLC (DHPLC). Methods …

Background/aims: Clarithromycin is an effective antibiotic for treating Helicobacter pylori;
however, the development clarithromycin-resistance by multiple strains prevents the …

ABSTRACT A single point mutation in the 23S rRNA gene of Helicobacter pylori is known to
confer resistance to clarithromycin. Most prevalent among clarithromycin-resistant clinical H …

Helicobacter pylori infections can be effectively treated with clarithromycin, a macrolide, in
combination with other antibiotics, such as amoxicillin, tetracycline or metronidazole. The …

Background It has not been fully confirmed whether the detection of Helicobacter pylori
resistance gene mutation can replace antibiotic drug sensitivity test to guide the clinical …

Primary clarithromycin resistance is the main factor affecting the efficacy of Helicobacter
pylori therapy. This study aimed:(i) to assess the concordance between phenotypic (culture) …

Polymerase chain reaction (PCR) for detection of single nucleotide mutations in 23S rRNA
gene of clarithromycin resistance Helicobacter pylori were investigated worldwide. In …

Abstract Background and Aim: As bacterial resistance to clarithromycin limits the efficacy of
clarithromycin‐based regimens for Helicobacter pylori infection, attention has turned to …

Background Resistance to clarithromycin and levofloxacin in Helicobacter pylori which
resulted in treatment failures has become a major challenge for physicians worldwide. The …