Real-Time PCR Assay for Rapid and Accurate Detection of Point Mutations Conferring Resistance to Clarithromycin in Helicobacter pylori

M Oleastro, A Ménard, A Santos… - Journal of clinical …, 2003 - Am Soc Microbiol
The main cause of failure of Helicobacter pylori eradication therapy is resistance to
clarithromycin. The resistance is due to three point mutations in two positions on the 23S …

Prevalence of primary clarithromycin resistance in Helicobacter pylori strains over a 15 year period in Italy

V De Francesco, M Margiotta, A Zullo… - Journal of …, 2007 - academic.oup.com
Objectives The frequency of primary clarithromycin resistance in Helicobacter pylori strains
is increasing worldwide, and its presence significantly reduces the treatment efficacy of …

Prevalence of Helicobacter pylori resistance to clarithromycin in Tunisia

L Chtourou, M Moalla, B Mnif… - Journal of Medical …, 2022 - microbiologyresearch.org
Background. Helicobacter pylori (H. pylori) resistance to clarithromycin is increasing
worldwide. Data on the prevalence of H. pylori resistance are limited in Tunisia. Gap …

Helicobacter pylori 23S rRNA gene mutations associated with clarithromycin resistance in chronic gastritis in Vietnam

TMT Ha, PTQ Le, VN Nguyen, TN Phan… - The Journal of Infection in …, 2018 - jidc.org
Introduction: Data about the prevalence of the A2142C, A2142G, and A2143G mutations in
23S rRNA gene is still limited. The aim of this study was to determine the prevalence of …

Molecular Characterization and Mutational Analysis of Clarithromycin- and Levofloxacin-Resistance Genes in Helicobacter pylori from Gastric Biopsies in Southern …

I Šamanić, B Dadić, Ž Sanader Maršić… - International journal of …, 2023 - mdpi.com
Point mutations in the 23S rRNA, gyrA, and gyrB genes can confer resistance to
clarithromycin (CAM) and levofloxacin (LVX) by altering target sites or protein structure …

[HTML][HTML] Prevalence of antibiotic resistance of Helicobacter pylori isolates in Shanghai, China

J Wang, X Xie, Z Zhong, H Yuan, P Xu… - American Journal of …, 2022 - ncbi.nlm.nih.gov
Objective: This study aimed to evaluate the resistance of Helicobacter pylori (H. pylori) to
common antibiotics in Shanghai. Methods: A total of 1171 eligible subjects participated in …

Characterisation of point mutations in domain V of the 23S rRNA gene of clinical Helicobacter pylori strains and clarithromycin-resistant phenotype in central Vietnam

TMT Ha, PTQ Le, TN Phan, TNH Tran - Journal of global antimicrobial …, 2019 - Elsevier
Objectives The prevalence of clarithromycin (CLR)-resistant Helicobacter pylori is increasing
worldwide, including in Vietnam. The aims of this study were to determine point mutations in …

Mutations affecting domain V of the 23S rRNA gene in Helicobacter pylori from Cairo, Egypt

D Ghaith, M Elzahry, G Mostafa, S Mostafa… - Journal of …, 2016 - Taylor & Francis
Background: Clarithromycin is a main component of the recommended first-line triple
therapy for Helicobacter pylori in Egypt. We aimed in our study to investigate the prevalence …

Gene mutations of 23S rRNA associated with clarithromycin resistance in Helicobacter pylori strains isolated from Korean patients

JM Kim, JS Kim, NY Kim, YJ Kim, IY Kim… - … of microbiology and …, 2008 - koreascience.kr
Although resistance of Helicobacter pylori to clarithromycin is a major cause of failure of
eradication therapies, little information is available regarding gene mutations of …

[PDF][PDF] Primary clarithromycin resistance in Helicobacter pylori: The multicentric Italian clarithromycin resistance observational (MICRO) study

V De Francesco, F Giorgio, E Ierardi, M Zotti… - J Gastrointestin …, 2011 - researchgate.net
Background. Primary clarithromycin resistance markedly reduces Helicobacter pylori
eradication rate following standard therapies. Prevalence of primary clarithromycin …