In different clinical studies, an association of type 2 diabetes and Alzheimer's disease (AD)
has been described. However, the underlying mechanisms are still unclear. One …

Aging is characterized by a significant decline of metabolic and hormonal functions, which
often facilitates the onset of severe age-associated pathologies. One outstanding example of …

Patients with type 2 diabetes (T2DM) have a two-to three-fold increased risk for Alzheimer's
disease (AD), the most common form of dementia. Vascular complications might explain …

Recent data suggest that brains of patients with Alzheimer's disease (AD) are insulin and
insulin-like growth factor-1 (IGF-1) resistant. So far, there have been two different …

The 'amyloid cascade hypothesis' proposes that disturbances in amyloid metabolism cause
Alzheimer's disease (AD). However, a comprehensive explanation of the mechanisms …

Aging is a major risk factor for Alzheimer's disease (AD). Insulin-like growth factor-1 receptor
(IGF-1R) regulates general aging and lifespan. However, the contribution of IGF-1 to age …

Insulin like growth factor-1 receptor (IGF-1R) and insulin receptor (IR) signalling control vital
growth, survival and metabolic functions in the brain. Here we describe specific and …

Alzheimer's disease (AD) is characterized by progressive neurodegeneration leading to loss
of cognitive abilities and ultimately to death. Postmortem investigations revealed decreased …

The neurodegeneration that occurs in sporadic Alzheimer's disease (AD) is consistently
associated with a number of characteristic histopathological, molecular, and biochemical …

Surprisingly little is known about the mechanisms that trigger the onset of AD (Alzheimer's
disease) in sporadic forms. A number of risk factors have been identified that may shed light …