A rare BRCA2 genetic variant, known as rs11571833 (K3326X), is strongly associated with
squamous-cell cancers of the upper aerodigestive tract (UADT), a new study reports. BRCA2 …

Deleterious BRCA2 genetic variants markedly increase risk of developing breast cancer. A
rare truncating BRCA2 genetic variant, rs11571833 (K3326X), has been associated with a …

An observational study examined the records of 19 581 women with BRCA1 mutations—of
whom 9052 (46%) developed breast cancer and 1041 (12%) ovarian cancer—and 11 900 …

On Feb 1, 2024, the National Health Service (NHS) in England launched a national BRCA
gene testing programme for all adults with Jewish ancestry (ie, at least one Jewish …

Inherited mutations in the BRCA1 gene confer a predisposition to breast and ovarian cancer.
1 We report the results of BRCA1-mutation screening in a family at high risk of breast and …

The incidence of esophageal squamous cell carcinoma (ESCC) is very high among the
Turkmen population of Iran. Family studies suggest a genetic component to the disease …

Women who carry the BRCA gene mutation that increases their risk of breast and ovarian
cancers might also be at higher risk of developing an aggressive form of uterine cancer …

Background Most pathogenic mutations in the BRCA2 gene carry a high risk of hereditary
breast and ovarian cancer (HBOC). However, a stop-gain mutation, K3326*(rs11571833) …

Germline mutations in the tumor suppressor genes BRCA1 and BRCA2 can increase the
risk of breast and/or ovarian cancer up to 20-fold. 1 Hundreds of different BRCA2 sequence …

See page 1337 The identification of BRCA1 in 19941 and BRCA2 in 19952 were landmarks
in the investigation of the genetics of breast cancer. Even before the genes were identified, it …