Natural killer cells in the synovial fluid of rheumatoid arthritis patients exhibit a CD56bright,CD94bright,CD158negative phenotype

C Pridgeon, GP Lennon, L Pazmany… - …, 2003 - academic.oup.com
Background. Natural killer (NK) cells play an important role in several animal models of
autoimmunity by modulating T‐cell responses, but it is unclear whether human NK cells …

A subset of natural killer cells is greatly expanded within inflamed joints

N Dalbeth, MFC Callan - … & Rheumatism: Official Journal of the …, 2002 - Wiley Online Library
Objective To determine whether natural killer (NK) cells are present within inflamed joints
and whether they might play a role in amplifying the inflammatory process. Methods Paired …

Altered natural killer cell subsets in seropositive arthralgia and early rheumatoid arthritis are associated with autoantibody status

P Chalan, J Bijzet, BJ Kroesen, AMH Boots… - The Journal of …, 2016 - jrheum.org
Objective. The role of natural killer (NK) cells in the immunopathogenesis of rheumatoid
arthritis (RA) is unclear. Therefore, numerical and functional alterations of CD56dim and …

Activating and inhibitory receptors on synovial fluid natural killer cells of arthritis patients: role of CD94/NKG2A in control of cytokine secretion

CT De Matos, L Berg, J Michaëlsson… - …, 2007 - Wiley Online Library
Natural killer (NK) cells are activated early during inflammatory events and contribute to the
shaping of the ensuing adaptive immune response. To further understand the role for NK …

A significantly impaired natural killer cell activity due to a low activity on a per-cell basis in rheumatoid arthritis

T Aramaki, H Ida, Y Izumi, K Fujikawa… - Modern …, 2009 - Taylor & Francis
To elucidate the characterization of peripheral natural killer (NK) cells in patients with
rheumatoid arthritis (RA), we investigated the NK cell activity, the expression of NK cell …

Natural killer cells and their role in rheumatoid arthritis: friend or foe?

H Shegarfi, F Naddafi… - The Scientific World …, 2012 - Wiley Online Library
Rheumatoid arthritis (RA) is a long‐term disease that leads to inflammation of the joints and
surrounding tissues. Natural killer (NK) cells are an important part of the innate immune …

The role of Natural Killer cells in the pathogenesis of rheumatoid arthritis: major contributors or essential homeostatic modulators?

DJ Ahern, FM Brennan - Immunology letters, 2011 - Elsevier
Natural Killer (NK) cells are lymphocytes of the innate immune system, originally described
by their capacity to control tumour cells and eliminate virus-infected cells. However …

Phenotype and function of natural killer cells in systemic lupus erythematosus: Excess interferon‐γ production in patients with active disease

B Hervier, V Beziat, J Haroche, A Mathian… - Arthritis & …, 2011 - Wiley Online Library
Objective To determine the phenotype and the functionality of natural killer (NK) cells in
patients with systemic lupus erythematosus (SLE). Methods A total of 94 patients with SLE …

Mobilization of natural killer cells inhibits development of collagen-induced arthritis

JW Leavenworth, X Wang… - Proceedings of the …, 2011 - National Acad Sciences
Although natural killer (NK) cells have been implicated in regulating immune responses,
their ability to modulate disease development in autoimmune arthritis has not been …

Peripheral blood but not synovial fluid natural killer T cells are biased towards a Th1-like phenotype in rheumatoid arthritis

L Linsen, M Thewissen, K Baeten, V Somers… - Arthritis research & …, 2005 - Springer
Natural killer T (NKT) cells have been implicated in the regulatory immune mechanisms that
control autoimmunity. However, their precise role in the pathogenesis of rheumatoid arthritis …