Why molnupiravir fails in hospitalized patients

AN Brown, Y Lang, J Zhou, EJ Franco, KC Hanrahan… - Mbio, 2022 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
coronavirus disease 2019 (COVID-19), has radically altered daily life. Effective antiviral …

[HTML][HTML] Insights into antiviral mechanisms of remdesivir, lopinavir/ritonavir and chloroquine/hydroxychloroquine affecting the new SARS-CoV-2

K Uzunova, E Filipova, V Pavlova, T Vekov - Biomedicine & …, 2020 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) is a kind of viral pneumonia with an unusual
outbreak in Wuhan, China, which is caused by severe acute respiratory syndrome …

Molnupiravir (EIDD-2801) inhibits SARS-CoV2 replication in Syrian hamsters model

R Abdelnabi, CS Foo, SJF Kaptein, X Zhang… - 2020 - pesquisa.bvsalud.org
Favipiravir and Molnupiravir, orally available antivirals, have been reported to exert antiviral
activity against SARS-CoV2. In recent days preliminary efficacy data have been reported in …

[HTML][HTML] Anti-viral treatment for SARS-CoV-2 infection: A race against time amidst the ongoing pandemic

NG Vallianou, D Tsilingiris, GS Christodoulatos… - Metabolism open, 2021 - Elsevier
Αbstract Remdesivir (GS-5734), a drug initially developed to treat hepatitis C and Ebola
virus disease, was the first approved treatment for severe coronavirus disease 2019 (COVID …

Evaluation of 19 antiviral drugs against SARS-CoV-2 Infection

S Liu, CZ Lien, P Selvaraj, TT Wang - BioRxiv, 2020 - biorxiv.org
The global pandemic of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2
or 2019-nCoV) has prompted multiple clinical trials to jumpstart search for anti-SARS-CoV-2 …

Efficacy and safety of molnupiravir for the treatment of SARS-CoV-2 infection: a systematic review and meta-analysis

JJ Malin, S Weibel, H Gruell… - Journal of …, 2023 - academic.oup.com
Background The role of molnupiravir for coronavirus disease 2019 (COVID-19) treatment is
unclear. Methods We conducted a systematic review until 1 November 2022 searching for …

[HTML][HTML] Treatment options for COVID-19: The reality and challenges

SS Jean, PI Lee, PR Hsueh - Journal of microbiology, immunology and …, 2020 - Elsevier
An outbreak related to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
was first reported in Wuhan, China in December 2019. An extremely high potential for …

[HTML][HTML] RdRp inhibitors and COVID-19: Is molnupiravir a good option?

SMR Hashemian, MH Pourhanifeh, MR Hamblin… - Biomedicine & …, 2022 - Elsevier
Rapid changes in the viral genome allow viruses to evade threats posed by the host immune
response or antiviral drugs, and can lead to viral persistence in the host cells. RNA …

Recent progress and challenges in drug development against COVID-19 coronavirus (SARS-CoV-2)-an update on the status

TM Abd El-Aziz, JD Stockand - Infection, Genetics and evolution, 2020 - Elsevier
Coronaviruses are a large group of viruses known to cause illnesses that vary between the
common cold and more severe diseases to include severe acute respiratory syndrome …

Current pharmacological treatments for SARS-COV-2: A narrative review

G Nittari, G Pallotta, F Amenta, SK Tayebati - European Journal of …, 2020 - Elsevier
The novel coronavirus, later identified as SARS-CoV-2, originating from Wuhan in China in
November 2019, quickly spread around the world becoming a pandemic. Despite the …