[HTML][HTML] Prostate cell differentiation status determines transient receptor potential melastatin member 8 channel subcellular localization and function

G Bidaux, M Flourakis, S Thebault… - The Journal of …, 2007 - Am Soc Clin Investig
In recent years, the transient receptor potential melastatin member 8 (TRPM8) channel has
emerged as a promising prognostic marker and putative therapeutic target in prostate …

PSA reduces prostate cancer cell motility by stimulating TRPM8 activity and plasma membrane expression

D Gkika, M Flourakis, L Lemonnier, N Prevarskaya - Oncogene, 2010 - nature.com
Although the transient receptor potential melastatin 8 (TRPM8) cold receptor is highly
expressed in prostate cancer (PCa) and constitutes a promising diagnostic and prognostic …

Novel role of cold/menthol-sensitive transient receptor potential melastatine family member 8 (TRPM8) in the activation of store-operated channels in LNCaP human …

S Thebault, L Lemonnier, G Bidaux, M Flourakis… - Journal of Biological …, 2005 - ASBMB
Recent cloning of a cold/menthol-sensitive TRPM8 channel (transient receptor potential
melastatine family member 8) from rodent sensory neurons has provided the molecular …

Menthol inhibits the proliferation and motility of prostate cancer DU145 cells

Y Wang, X Wang, Z Yang, G Zhu, D Chen… - Pathology & Oncology …, 2012 - Springer
In recent years, the transient receptor potential melastatin member 8 (TRPM8) channel has
emerged as a promising prognostic marker and putative therapeutic target in prostate …

TRPM8 puts the chill on prostate cancer

GP Grolez, D Gkika - Pharmaceuticals, 2016 - mdpi.com
Prostate cancer (PCa) is one of the most frequently diagnosed cancers in developed
countries. Several studies suggest that variations in calcium homeostasis are involved in …

TRPM8-androgen receptor association within lipid rafts promotes prostate cancer cell migration

GP Grolez, DV Gordiendko, M Clarisse… - Cell death & …, 2019 - nature.com
In prostate carcinogenesis, androgens are known to control the expression of the transient
receptor potential melastatin 8 (TRPM8) protein via activation of androgen receptor (AR) …

Evidence for specific TRPM8 expression in human prostate secretory epithelial cells: functional androgen receptor requirement

G Bidaux, M Roudbaraki, C Merle… - Endocrine-related …, 2005 - erc.bioscientifica.com
TRPM8 (melastatine-related transient receptor potential member 8), a member of the
transient receptor potential (TRP) superfamily of cation channels, has been shown to be a …

[HTML][HTML] Transient receptor potential melastatin 4 channel contributes to migration of androgen-insensitive prostate cancer cells

C Holzmann, S Kappel, T Kilch, MM Jochum… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Impaired Ca 2+ signaling in prostate cancer contributes to several cancer hallmarks, such as
enhanced proliferation and migration and a decreased ability to induce apoptosis. Na+ …

TRPM4 channel is involved in regulating epithelial to mesenchymal transition, migration, and invasion of prostate cancer cell lines

AI Sagredo, EA Sagredo, V Pola… - Journal of Cellular …, 2019 - Wiley Online Library
Abstract Transient Receptor Potential Melastatin 4 (TRPM4) is a Ca2+‐activated and voltage‐
dependent monovalent cation channel, which depolarizes the plasma cell membrane …

Transient receptor potential melastatin‐related 7 channel is overexpressed in human pancreatic ductal adenocarcinomas and regulates human pancreatic cancer cell …

P Rybarczyk, M Gautier, F Hague… - … journal of cancer, 2012 - Wiley Online Library
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive forms of cancer
with a tendency to invade surrounding healthy tissues, leading to a largely incurable …