The accumulation and aggregation of the amyloid-β peptide (Aβ) in the brain are important
contributing factors to Alzheimer's disease (AD). Consequently, blocking the generation of …

Recent results implicating cholesterol metabolism in the pathophysiology of Alzheimer's
disease (AD) bring cholesterol to the forefront of AD research. Research from genetics …

The basis for therapeutic strategies targeting the amyloid-β protein (Aβ) has come from
studies showing that accumulation and aggregation of the Aβ within the brain is likely to …

Cholesterol has been implicated in the pathogenesis of Alzheimer's disease, both through
intracellular effects, and through an extracellular effect due to its physical interaction with …

Alzheimer disease (AD) is an age-related neurodegenerative disorder that manifests as a
progressive loss of memory and deterioration of higher cognitive functions. Alzheimer …

Alzheimer's disease (AD) is the most common cause of dementia in North America and
Europe. The incidence of the disease rises dramatically with age. AD is a complex …

A leading hypothesis on the pathophysiology of Alzheimer's disease (AD) is the mis-
metabolism of amyloid precursor protein. This mis-metabolism causes the 42-amino acid …

The past 4 years have seen a growing interest in cholesterol metabolism and its relationship
to Alzheimer's disease. From the first report linking cholesterol and β-amyloid metabolisms …

Alzheimer's disease (AD), the most common form of dementia, is characterized by the
progressive loss of neurons and synapses, and by extracellular deposits of amyloid‐β (Aβ) …

The implication that cholesterol plays an essential role in the pathogenesis of Alzheimer's
disease (AD) is based on the 1993 finding that the presence of apolipoprotein E (apoE) …