Small-molecule PSMA ligands. Current state, SAR and perspectives

AE Machulkin, YA Ivanenkov… - Journal of drug …, 2016 - Taylor & Francis
Prostate cancer (PC) is the prevalent malignancy widespread among men in the Western
World. Prostate specific membrane antigen (PSMA) is an established PC marker and has …

PSMA ligands in prostate cancer–Probe optimization and theranostic applications

S Lütje, R Slavik, W Fendler, K Herrmann, M Eiber - Methods, 2017 - Elsevier
Due to its selective overexpression in prostate cancer (PCa), the prostate-specific
membrane antigen (PSMA) has been recognized as a highly promising target for diagnostic …

The importance of linkers in the structure of PSMA ligands

AA Uspenskaya, EA Nimenko… - Current Medicinal …, 2022 - ingentaconnect.com
Cancer is one of the leading social problems of the modern world. Today prostate cancer is
the second leading cause of cancer deaths among men. Targeted drug delivery is widely …

PSMA-targeting imaging and theranostic agents—Current status and future perspective

S Debnath, N Zhou, M McLaughlin, S Rice… - International journal of …, 2022 - mdpi.com
In the past two decades, extensive efforts have been made to develop agents targeting
prostate-specific membrane antigen (PSMA) for prostate cancer imaging and therapy. To …

Development of PSMA-1007-Related Series of 18F-Labeled Glu-Ureido-Type PSMA Inhibitors

J Cardinale, M Roscher, M Schäfer… - Journal of medicinal …, 2020 - ACS Publications
In recent years, a number of drugs targeting the prostate-specific membrane antigen (PSMA)
have become important tools in the diagnosis and treatment of prostate cancer. In the …

Preclinical Evaluation of a PSMA-Targeting Homodimer with an Optimized Linker for Imaging of Prostate Cancer

E Murce, S Beekman, E Spaan, M Handula… - Molecules, 2023 - mdpi.com
Prostate-specific membrane antigen (PSMA) targeting radiopharmaceuticals have been
successfully used for diagnosis and therapy of prostate cancer. Optimization of the available …

[HTML][HTML] PSMA ligands for radionuclide imaging and therapy of prostate cancer: clinical status

S Lütje, S Heskamp, AS Cornelissen, TD Poeppel… - Theranostics, 2015 - ncbi.nlm.nih.gov
Prostate cancer (PCa) is the most common malignancy in men worldwide, leading to
substantial morbidity and mortality. At present, imaging of PCa has become increasingly …

Prostate-specific membrane antigen targeted imaging and therapy of prostate cancer using a PSMA inhibitor as a homing ligand

SA Kularatne, K Wang, HKR Santhapuram… - Molecular …, 2009 - ACS Publications
Prostate cancer (PCa) is a major cause of mortality and morbidity in Western society today.
Current methods for detecting PCa are limited, leaving most early malignancies …

[HTML][HTML] Advances in PSMA theranostics

TM Jeitner, JW Babich, JM Kelly - Translational Oncology, 2022 - Elsevier
The validation of prostate specific membrane antigen (PSMA) as a molecular target in
metastatic castration-resistant prostate cancer has stimulated the development of multiple …

Recent advances in prostate-specific membrane antigen-based radiopharmaceuticals

W Diao, H Cai, L Chen, X Jin, X Liao… - Current Topics in …, 2019 - ingentaconnect.com
Background: Prostate cancer (PCa) is the most common sex-related malignancy with high
mortality in men worldwide. Prostate-specific membrane antigen (PSMA) is overexpressed …