Plasma ceramides predict cardiovascular death in patients with stable coronary artery disease and acute coronary syndromes beyond LDL-cholesterol

R Laaksonen, K Ekroos, M Sysi-Aho… - European heart …, 2016 - academic.oup.com
Aims The aim was to study the prognostic value of plasma ceramides (Cer) as
cardiovascular death (CV death) markers in three independent coronary artery disease …

Plasma ceramides: a novel predictor of major adverse cardiovascular events after coronary angiography

JW Meeusen, LJ Donato, SC Bryant… - … , and vascular biology, 2018 - Am Heart Assoc
Objective—Ceramides are sphingolipids involved with cellular signaling. Synthesis of
ceramides occurs in all tissues. Ceramides accumulate within tissues and the blood plasma …

Development and validation of a ceramide-and phospholipid-based cardiovascular risk estimation score for coronary artery disease patients

M Hilvo, PJ Meikle, ER Pedersen, GS Tell… - European heart …, 2020 - academic.oup.com
Aims Distinct ceramide lipids have been shown to predict the risk for cardiovascular disease
(CVD) events, especially cardiovascular death. As phospholipids have also been linked with …

[HTML][HTML] Plasma concentrations of molecular lipid species predict long-term clinical outcome in coronary artery disease patients

S Anroedh, M Hilvo, KM Akkerhuis, D Kauhanen… - Journal of lipid …, 2018 - ASBMB
We investigated the associations of ten previously identified high risk molecular lipid species
and three ceramide ratios with the occurrence of major adverse cardiac events (MACEs) …

[HTML][HTML] Could ceramides become the new cholesterol?

SA Summers - Cell metabolism, 2018 - cell.com
The Mayo Clinic recently introduced a diagnostic test that quantifies plasma ceramides in
order to identify patients at risk of major adverse cardiac events. By comparing recent …

Plasma ceramides as prognostic biomarkers and their arterial and myocardial tissue correlates in acute myocardial infarction

LP de Carvalho, SH Tan, GS Ow, Z Tang… - JACC: Basic to …, 2018 - jacc.org
We identified a plasma signature of 11 C14 to C26 ceramides and 1 C16 dihydroceramide
predictive of major adverse cardiovascular events in patients with acute myocardial …

Circulating ceramides predict cardiovascular outcomes in the population-based FINRISK 2002 cohort

AS Havulinna, M Sysi-Aho, M Hilvo… - … , and vascular biology, 2016 - Am Heart Assoc
Objective—Ceramides are molecular lipids implicated in apoptosis, inflammation, obesity,
and insulin resistance. An earlier study reported that ceramides were associated with fatal …

Development and validation of a high-throughput LC–MS/MS assay for routine measurement of molecular ceramides

D Kauhanen, M Sysi-Aho, KM Koistinen… - Analytical and …, 2016 - Springer
Monitoring the levels of the ceramides (Cer) d18: 1/16: 0, Cer d18: 1/18: 0, Cer d18: 1/24: 0,
and Cer d18: 1/24: 1 and ratios thereof in human plasma empowers the prediction of fatal …

Ceramides and risk of major adverse cardiovascular events: a meta-analysis of longitudinal studies

A Mantovani, C Dugo - Journal of Clinical Lipidology, 2020 - Elsevier
Background Recent cohort studies evaluated the association between some previously
identified high-risk ceramides [Cer (d18: 1/16: 0), Cer (d18: 1/18: 0), Cer (d18: 1/22: 0), Cer …

Ceramide remodeling and risk of cardiovascular events and mortality

LR Peterson, V Xanthakis, MS Duncan… - Journal of the …, 2018 - Am Heart Assoc
Background Recent studies suggest that circulating concentrations of specific ceramide
species may be associated with coronary risk and mortality. We sought to determine the …