Porphyromonas gingivalis-Induced Cognitive Impairment Is Associated With Gut Dysbiosis, Neuroinflammation, and Glymphatic Dysfunction

L Chi, X Cheng, L Lin, T Yang, J Sun, Y Feng… - Frontiers in Cellular …, 2021 - frontiersin.org
Background Periodontal pathogen and gut microbiota are closely associated with the
pathogenesis of Alzheimer's disease (AD). Porphyromonas gingivalis (Pg), the keystone …

Oral pathogenic bacteria-inducing neurodegenerative microgliosis in human neural cell platform

VTA Tran, YJ Kang, HK Kim, HR Kim… - International Journal of …, 2021 - mdpi.com
Porphyromonas gingivalis is a gram-negative bacterium found in the human oral cavity and
is responsible for the development of chronic periodontitis as well as neurological diseases …

Porphyromonas gingivalis: A key role in Parkinson's disease with cognitive impairment?

D Li, T Ren, H Li, G Liao, X Zhang - Frontiers in Neurology, 2022 - frontiersin.org
Cognitive impairment (CI) is a common complication of Parkinson's disease (PD). The major
features of Parkinson's disease with cognitive impairment (PD-CI) include convergence of α …

[HTML][HTML] Extracellular vesicles derived from Porphyromonas gingivalis induce trigeminal nerve-mediated cognitive impairment

X Ma, YJ Shin, JW Yoo, HS Park, DH Kim - Journal of Advanced Research, 2023 - Elsevier
Introduction Porphyromonas gingivalis (PG)-infected periodontitis is in close connection with
the development of Alzheimer's disease (AD). PG-derived extracellular vesicles (pEVs) …

Exogenous monocyte myeloid-derived suppressor cells ameliorate immune imbalance, neuroinflammation and cognitive impairment in 5xFAD mice infected with …

X Cheng, L Chi, T Lin, F Liang, Z Pei, J Sun… - Journal of …, 2023 - Springer
Background Periodontitis is closely associated with the pathogenesis of Alzheimer's disease
(AD). Porphyromonas gingivalis (Pg), the keystone periodontal pathogen, has been reported …

Porphyromonas gingivalis-induced periodontitis could contribute to cognitive impairment in Sprague–Dawley rats via the P38 MAPK signaling pathway

R Jin, X Ning, X Liu, Y Zhao, G Ye - Frontiers in Cellular …, 2023 - frontiersin.org
Background Periodontitis is one of the most common oral diseases and has been shown to
be a risk factor for systemic diseases. Our aim was to investigate the relationship between …

Porphyromonas gingivalis lipopolysaccharide induces cognitive dysfunction, mediated by neuronal inflammation via activation of the TLR4 signaling pathway in …

J Zhang, C Yu, X Zhang, H Chen, J Dong, W Lu… - Journal of …, 2018 - Springer
Background Porphyromonas gingivalis lipopolysaccharide (P. gingivalis-LPS) is one of the
major pathogenic factors of chronic periodontitis (CP). Few reports on the correlation …

Porphyromonas gingivalis, a periodontitis causing bacterium, induces memory impairment and age-dependent neuroinflammation in mice

Y Ding, J Ren, H Yu, W Yu, Y Zhou - Immunity & Ageing, 2018 - Springer
Background A possible relationship between periodontitis and Alzheimer's disease (AD) has
been reported. However, there is limited information on the association between the …

Periodontitis-related salivary microbiota aggravates Alzheimer's disease via gut-brain axis crosstalk

J Lu, S Zhang, Y Huang, J Qian, B Tan, X Qian… - Gut …, 2022 - Taylor & Francis
The oral cavity is the initial chamber of digestive tract; the saliva swallowed daily contains an
estimated 1.5× 1012 oral bacteria. Increasing evidence indicates that periodontal pathogens …

Periodontal infection aggravates C1q-mediated microglial activation and synapse pruning in Alzheimer's mice

X Hao, Z Li, W Li, J Katz, SM Michalek… - Frontiers in …, 2022 - frontiersin.org
Periodontitis is a dysbiotic infectious disease that leads to the destruction of tooth supporting
tissues. There is increasing evidence that periodontitis may affect the development and …