The nucleolar protein hUTP14a promotes p53 degradation and possesses an oncogene
potential. Here, we report that hUTP14a promotes degradation of tumor suppressor …

The ubiquitin conjugating enzyme Ube2g2 together with its cognate E3 ligase gp78
catalyzes the synthesis of lysine-48 polyubiquitin chains constituting signals for the …

Transfer of ubiquitin to substrate proteins regulates most processes in eukaryotic cells. E2
enzymes are a central component of the ubiquitin machinery, and generally determine the …

The ubiquitin (Ub)-conjugating enzymes Ubc4 and Ubc5 are involved in a variety of
ubiquitination pathways in yeast, including Rsp5-and anaphase-promoting complex (APC) …

For many E3 ligases, a mobile RING (Really Interesting New Gene) domain stimulates
ubiquitin (Ub) transfer from a thioester-linked E2∼ Ub intermediate to a lysine on a remotely …

The U box is a domain of∼ 70 amino acids that is present in proteins from yeast to humans.
The prototype U box protein, yeast Ufd2, was identified as a ubiquitin chain assembly factor …

Ubiquitin binding domains (UBDs) are modular elements that bind non-covalently to
ubiquitin and act as downstream effectors and amplifiers of the ubiquitination signal. With …

The Really Interesting New Gene (RING) Finger protein 11 (RNF 11) is a subunit of the A20
ubiquitin‐editing complex that ensures the transient nature of inflammatory responses …

Functional analysis of lysine 27-linked ubiquitin chains (K27 Ub) is difficult due to the
inability to make them through enzymatic methods and due to a lack of model tools and …

Cells have quality-control mechanisms to recognize non-native protein structures and either
help the proteins fold or promote their degradation,. Ubiquitin-conjugating enzymes (E2s) …