Objective To evaluate the contribution of sensory neurons in ankle joints and adjacent tissue
to the development of pain in collagen‐induced arthritis (CIA), and to determine the …

Objective Pain is a prominent feature of osteoarthritis (OA). To further understand the
primary mechanisms of nociception in OA, we studied the expression of the phenotype …

Objective To investigate the role of the sensory neuropeptide calcitonin gene‐related
peptide (CGRP) in peripheral sensitization in experimental models of osteoarthritis (OA) …

Background Rheumatoid arthritis (RA) patients frequently show weak correlations between
the magnitude of pain and inflammation suggesting that mechanisms other than overt …

The mechanisms underlying rheumatoid arthritis (RA)‐induced pain are still not fully
elucidated, and accumulating data indicate that peripheral inflammation is not the only factor …

Abstract Introduction Interleukin-6 (IL-6) is an important mediator of inflammation. In addition
to cells involved in inflammation, sensory nociceptive neurons express the IL-6 signal …

Objective In arthritis, macrophages invade the affected joint. Experimental arthritis models
have shown that macrophages also invade the dorsal root ganglia (DRGs) of the inflamed …

The role of calcitonin gene related peptide (CGRP) in neuropathic pain was investigated in a
mouse model of neuropathic pain, spinal nerve L5 transection (L5Tx). Intrathecal injection …

Background Osteoarthritis (OA) is a highly prevalent, age‐related pain condition that poses
a significant clinical problem. Here, in the monosodium iodoacetate (MIA) model of OA, we …

Calcitonin gene-related peptide is involved in peripheral and spinal mechanisms of
inflammatory pain. In this paper, we used collagen II-induced arthritis in the rat as a model to …