Biological processes are governed by complex networks ranging from gene regulation to
signal transduction. Positive feedback is a key element in such networks. The regulation …

Feedback is a ubiquitous control mechanism of gene networks. Here, we have used positive
feedback to construct a synthetic eukaryotic gene switch in Saccharomyces cerevisiae …

Positive feedback loops are regulatory elements that can modulate expression output,
kinetics and noise in genetic circuits. Transcriptional regulators participating in such loops …

Positive and negative feedback loops are often coupled to perform various functions in gene
regulatory networks, acting as bistable switches, oscillators, and excitable devices. It is …

Cells regulate gene expression using networks of transcription interactions; it is of interest to
discover the principles that govern the dynamical behavior of such networks. An important …

In this paper, we propose a theoretical framework to systematically analyze the existence
and the profiles of chemical oscillations in gene regulatory networks with negative cyclic …

The transient response to a stimulus and subsequent recovery to a steady state are the
fundamental characteristics of a living organism. Here we study the relaxation kinetics of …

Organisms are equipped with regulatory systems that display a variety of dynamical
behavior ranging from simple stable steady states, to switching and multistability, to …

A common topology found in many bistable genetic systems is two interacting positive
feedback loops. Here we explore how this relatively simple topology can allow bistability …

Oscillators and switches are ubiquitous in gene regulatory networks. Understanding the
dynamical properties of these systems is a necessity not only to reverse engineer their …