Recent efforts by both academic and pharmaceutical researchers have focused on the HIV-1
capsid (CA) protein as a new therapeutic target. An interprotomer pocket within the hexamer …

Background: The infectious human immunodeficiency virus (HIV) particle is characterized by
a conical capsid that encloses the viral RNA genome. The capsid is essential for HIV-1 …

HIV-1 capsid protein (CA) plays an important role in many steps of viral replication and
represents an appealing antiviral target. Several CA-targeting small molecules of various …

The HIV-1 capsid (CA) protein, a domain of Gag, which participates in formation of both the
mature and immature capsid, represents a potential target for anti-viral drug development …

The HIV-1 CA protein has gained remarkable attention as a promising therapeutic target for
the development of new antivirals, due to its pivotal roles in HIV-1 replication (structural and …

Recently reported HIV-1 capsid (CA) inhibitors GS-CA1 and GS-6207 (an analog of GS-
CA1) are first-in-class compounds with long-acting potential. Reportedly, both compounds …

The capsid (CA) protein is the major structural component of HIV-1 and plays a key role in
the regulation of viral life cycle. Inhibition of CA will affect the viral assembly and budding …

Introduction Although combination antiretroviral therapy (cART) has achieved significant
success in treating HIV, the emergence of multidrug-resistant viruses and cumulative …

Human immunodeficiency virus (HIV) capsid (CA) protein is a promising target for
developing novel anti‐HIV drugs. Starting from highly anticipated CA inhibitors PF‐74, we …

The capsid protein (CA) of HIV-1 plays essential roles in multiple steps of the viral replication
cycle by assembling into functional capsid core, controlling the kinetics of uncoating and …