For more than 40 years now, the developing kidney has served as a model paradigm for
epithelial‐mesenchymal interactions. The principles of inductive signaling, epithelial cell …

Although it is not easy to investigate the regulatory basis of developmental processes in
most mammalian tissues, the mouse kidney has several distinct advantages as a model …

Mechanisms governing the biogenesis of the epithelial phenotype have been the focus of
increasing attention in recent years. With respect to kidney development, investigators have …

The mammalian kidney is a vital organ with considerable cellular complexity and functional
diversity. Kidney development is notable for requiring distinct but coincident tubulogenic …

Embryonic kidney is ideal for the study of epithelial morphogenesis—rich in developmental
processes, accessible and clinically important. Interactions between mesenchyme and the …

Publisher Summary Kidney development is characterized by the formation of epithelial
tubules from mesodermal mesenchymal cells and a subsequent series of interactions of the …

Kidney development starts with an epithelial bud and a domain of committed mesenchyme
inducing one another so that the former gives a bifurcating duct system and the latter …

The study of kidney development and maintenance is critical in understanding the
progression of human disease. Disruption of renal development can give rise to congenital …

The kidney plays an essential role during excretion of metabolic waste products,
maintenance of key homeostasis components such as ion concentrations and hormone …

The development of the mature mammalian kidney begins with the invasion of metanephric
mesenchyme by ureteric bud. Mesenchymal cells near the bud become induced and convert …