Predicting adverse side effects of drugs
Background Studies of toxicity and unintended side effects can lead to improved drug safety
and efficacy. One promising form of study comes from molecular systems biology in the form …
and efficacy. One promising form of study comes from molecular systems biology in the form …
Large-scale prediction of adverse drug reactions using chemical, biological, and phenotypic properties of drugs
Objective Adverse drug reaction (ADR) is one of the major causes of failure in drug
development. Severe ADRs that go undetected until the post-marketing phase of a drug …
development. Severe ADRs that go undetected until the post-marketing phase of a drug …
Predicting adverse drug reaction profiles by integrating protein interaction networks with drug structures
The prediction of adverse drug reactions (ADRs) has become increasingly important, due to
the rising concern on serious ADRs that can cause drugs to fail to reach or stay in the …
the rising concern on serious ADRs that can cause drugs to fail to reach or stay in the …
INDI: a computational framework for inferring drug interactions and their associated recommendations
A Gottlieb, GY Stein, Y Oron, E Ruppin… - Molecular systems …, 2012 - embopress.org
Inferring drug–drug interactions (DDIs) is an essential step in drug development and drug
administration. Most computational inference methods focus on modeling drug …
administration. Most computational inference methods focus on modeling drug …
Determining molecular predictors of adverse drug reactions with causality analysis based on structure learning
Objective Adverse drug reaction (ADR) can have dire consequences. However, our current
understanding of the causes of drug-induced toxicity is still limited. Hence it is of paramount …
understanding of the causes of drug-induced toxicity is still limited. Hence it is of paramount …
A structure-based approach for mapping adverse drug reactions to the perturbation of underlying biological pathways
I Wallach, N Jaitly, R Lilien - PloS one, 2010 - journals.plos.org
Adverse drug reactions (ADR), also known as side-effects, are complex undesired
physiologic phenomena observed secondary to the administration of pharmaceuticals …
physiologic phenomena observed secondary to the administration of pharmaceuticals …
Metabolic network prediction of drug side effects
Drug side effects levy a massive cost on society through drug failures, morbidity, and
mortality cases every year, and their early detection is critically important. Here, we describe …
mortality cases every year, and their early detection is critically important. Here, we describe …
In silico assessment of adverse drug reactions and associated mechanisms
SM Ivanov, AA Lagunin, VV Poroikov - Drug Discovery Today, 2016 - Elsevier
Highlights•Early assessment of adverse drug reactions (ADRs) requires knowledge of their
mechanisms.•Chemical and biological drug features can be used for assessment of …
mechanisms.•Chemical and biological drug features can be used for assessment of …
Improving drug safety: From adverse drug reaction knowledge discovery to clinical implementation
Adverse drug reactions (ADRs) are a major public health concern, causing over 100,000
fatalities in the United States every year with an annual cost of $136 billion. Early detection …
fatalities in the United States every year with an annual cost of $136 billion. Early detection …
[HTML][HTML] Exploring the associations between drug side-effects and therapeutic indications
Drug therapeutic indications and side-effects are both measurable patient phenotype
changes in response to the treatment. Inferring potential drug therapeutic indications and …
changes in response to the treatment. Inferring potential drug therapeutic indications and …