Hepcidin is the key regulator of systemic iron availability that acts by controlling the
degradation of the iron exporter ferroportin. It is expressed mainly in the liver and regulated …

Hepcidin is considered the major regulator of systemic iron homeostasis in human and mice,
and its expression in the liver is mainly regulated at a transcriptional level. Central to its …

Hepcidin is a liver-derived peptide hormone that controls systemic iron homeostasis. Its
expression is regulated by the bone morphogenetic protein 6 (BMP6)/SMAD1/5/8 pathway …

Heparanase is elevated in various pathological conditions, primarily cancer and
inflammation. To investigate the significance and involvement of heparanase in liver fibrosis …

Heparanase is an endo-glucuronidase that degrades heparan sulfate chains. The enzyme is
expressed at a low level in normal organs; however, elevated expression of heparanase has …

Hepcidin, which has been recently identified both by biochemical and genomic approaches,
is a 25 amino acid polypeptide synthesized mainly by hepatocytes and secreted into the …

In 2019, we mark the 20th anniversary of the cloning of the human heparanase gene.
Heparanase remains the only known enzyme to cleave heparan sulfate, which is an …

The hepatic hormone hepcidin is the master regulator of systemic iron homeostasis. Its
expression level is adjusted to alterations in iron levels, inflammatory cues, and iron …

BACKGROUND/AIMS: The antimicrobial peptide hepcidin is generated in the liver and
released into the circulation in response to iron, oxygen and inflammatory signals. Hepcidin …

Heparanase is an endo-β-D-glucuronidase capable of cleaving heparan sulfate (HS) side
chains at a limited number of sites, yielding HS fragments of still appreciable size (∼ 5–7 …