[HTML][HTML] Macrophage activation-like syndrome: a distinct entity leading to early death in sepsis

E Karakike, EJ Giamarellos-Bourboulis - Frontiers in immunology, 2019 - frontiersin.org
Hemophagocytic lymphohistocytosis (HLH) is characterized by fulminant cytokine storm
leading to multiple organ dysfunction and high mortality. HLH is classified into familial …

[HTML][HTML] Macrophage activation-like syndrome: an immunological entity associated with rapid progression to death in sepsis

E Kyriazopoulou, K Leventogiannis, A Norrby-Teglund… - BMC medicine, 2017 - Springer
Background A subanalysis of a randomized clinical trial indicated sepsis survival benefit
from interleukin (IL)-1 blockade in patients with features of the macrophage activation-like …

Macrophage activation syndrome: characteristic findings on liver biopsy illustrating the key role of activated, IFN-γ-producing lymphocytes and IL-6-and TNF-α …

AD Billiau, T Roskams, R Van Damme-Lombaerts… - Blood, 2005 - ashpublications.org
Macrophage activation syndrome (MAS) is a rare and potentially fatal disorder, thought to
result from uncontrolled activation and proliferation of T cells and excessive activation of …

Macrophage activation syndrome: early diagnosis is key

B Lerkvaleekul, S Vilaiyuk - Open access rheumatology: research …, 2018 - Taylor & Francis
Macrophage activation syndrome (MAS) is a life-threatening condition, and it is a subset of
hemophagocytic lymphohistiocytosis (HLH). The clinical features include a persistent high …

Cytokine storm syndrome

RQ Cron, G Goyal, WW Chatham - Annual Review of Medicine, 2023 - annualreviews.org
Cytokine storm syndrome (CSS), which is frequently fatal, has garnered increased attention
with the ongoing coronavirus pandemic. A variety of hyperinflammatory conditions …

Macrophage activation syndrome in adults: recent advances in pathophysiology, diagnosis and treatment

SJ Carter, RS Tattersall, AV Ramanan - Rheumatology, 2019 - academic.oup.com
Haemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome, which if not
promptly treated, can lead rapidly to critical illness and death. HLH is termed macrophage …

Pathogenesis of macrophage activation syndrome and potential for cytokine-directed therapies

GS Schulert, AA Grom - Annual review of medicine, 2015 - annualreviews.org
Macrophage activation syndrome (MAS) is an acute episode of overwhelming inflammation
characterized by activation and expansion of T lymphocytes and hemophagocytic …

The genetics of macrophage activation syndrome

GS Schulert, RQ Cron - Genes & Immunity, 2020 - nature.com
Macrophage activation syndrome (MAS), or secondary hemophagocytic lymphohistiocytosis
(HLH), is a cytokine storm syndrome associated with multi-organ system dysfunction and …

[PDF][PDF] Coagulation disorders in hemophagocytic lymphohistiocytosis/macrophage activation syndrome

S Valade, E Mariotte, E Azoulay - Critical care clinics, 2020 - Elsevier
HLH is a rare condition that can be responsible of life-threatening organ failure. The
pathophysiology relies on a defect of cytotoxicity resulting in an uncontrolled inflammatory …

A personalized diagnostic and treatment approach for macrophage activation syndrome and secondary hemophagocytic lymphohistiocytosis in adults

B Kumar, S Aleem, H Saleh, J Petts… - Journal of Clinical …, 2017 - Springer
Objective We assessed the clinical features and outcomes based on therapeutic options
adopted during hospital stay for adult patients with macrophage activation syndrome and …