Differentiation resistance through altered retinoblastoma protein function in acute lymphoblastic leukemia: in silico modeling of the deregulations in the G1/S restriction …
Background As in many cancer types, the G1/S restriction point (RP) is deregulated in Acute
Lymphoblastic Leukemia (ALL). Hyper-phosphorylated retinoblastoma protein (hyper-pRb) …
Lymphoblastic Leukemia (ALL). Hyper-phosphorylated retinoblastoma protein (hyper-pRb) …
Modeling and Simulating Carcinogenesis
J Groten, A Venkatraman, R Mertelsmann - Precision Medicine, 2018 - Elsevier
The overall aim of this project was to investigate the fundamental phenotypic traits of a
cancer cell in order to develop a primary “in silico” simulation model and reinvestigate the …
cancer cell in order to develop a primary “in silico” simulation model and reinvestigate the …
Towards a systems biology approach to mammalian cell cycle: modeling the entrance into S phase of quiescent fibroblasts after serum stimulation
Background The cell cycle is a complex process that allows eukaryotic cells to replicate
chromosomal DNA and partition it into two daughter cells. A relevant regulatory step is in the …
chromosomal DNA and partition it into two daughter cells. A relevant regulatory step is in the …
Pathway simulations in common oncogenic drivers of leukemic and rhabdomyosarcoma cells: a systems biology approach
GI Lambrou, A Zaravinos… - International …, 2012 - spandidos-publications.com
A part of current research has intensively been focused on the proliferation and metabolic
processes governing biological systems. Since the advent of high throughput methodologies …
processes governing biological systems. Since the advent of high throughput methodologies …
CDK2 catalytic activity and loss of nuclear tethering of retinoblastoma protein in childhood acute lymphoblastic leukemia
NMR Schmitz, K Leibundgut, A Hirt - Leukemia, 2005 - nature.com
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. During cell cycle
progression from the mid-to late G 1 phase, mammalian cells traverse the restriction point, a …
progression from the mid-to late G 1 phase, mammalian cells traverse the restriction point, a …
Systems Approaches in the Common Metabolomics in Acute Lymphoblastic Leukemia and Rhabdomyosarcoma Cells: A Computational Approach
Acute lymphoblastic leukemia is the most common childhood malignancy.
Rhabdomyosarcoma, on the other hand, is a rare type of malignancy which belongs to the …
Rhabdomyosarcoma, on the other hand, is a rare type of malignancy which belongs to the …
Modeling and analysis of retinoic acid induced differentiation of uncommitted precursor cells
Manipulation of differentiation programs has therapeutic potential in a spectrum of human
cancers and neurodegenerative disorders. In this study, we integrated computational and …
cancers and neurodegenerative disorders. In this study, we integrated computational and …
A new stochastic model of carcinogenesis induced by ionizing radiation and the concept of breaking barrier cell mechanisms
[en] In this report we present a new multiple-pathway dynamic stochastic model of leukemia
development, which combines and further extends ideas used in: i) models of hematopoietic …
development, which combines and further extends ideas used in: i) models of hematopoietic …
The Src-family kinase inhibitor PP2 rescues inducible differentiation events in emergent retinoic acid-resistant myeloblastic leukemia cells
HA Jensen, LE Styskal, R Tasseff, RP Bunaciu… - PLoS …, 2013 - journals.plos.org
Retinoic acid is an embryonic morphogen and dietary factor that demonstrates
chemotherapeutic efficacy in inducing maturation in leukemia cells. Using HL60 model …
chemotherapeutic efficacy in inducing maturation in leukemia cells. Using HL60 model …
Tackling Acute Lymphoblastic Leukemia—One Fish at a Time
Despite advancements in the diagnosis and treatment of acute lymphoblastic leukemia
(ALL), a need for improved strategies to decrease morbidity and improve cure rates in …
(ALL), a need for improved strategies to decrease morbidity and improve cure rates in …