In silico models and computer simulation are invaluable tools to better understand complex
biological processes such as cancer evolution. However, the complexity of the biological …

Cell proliferation is regulated by the cell cycle, and in order to divide the cell must enter a
mitotic state. Prior to mitosis the cell is required to pass through a number of checkpoints …

Increased intracellular levels of cAMP, induced by forskolin, lead to permanent G1 arrest of
Reh cells. As expected, we observed a rapid dephosphorylation of the retinoblastoma …

Patients with myeloid neoplasia are classified by the WHO classification systems. Besides
clinical and hematological criteria, cytogenetic and molecular genetic alterations highly …

The retinoblastoma tumor suppressor, RB, is a key regulator of cellular proliferation that is
functionally inactivated at high frequency in human cancer. Although RB has been …

In silico biology, the computer aided analysis of biological systems, is a relatively young
research area. It was first coined from theoretical and computational biology. Biology, like …

Cancer is still one of the major causes of death worldwide. Even if its comprehension is
improving continuously, the complexity and heterogeneity of this group of diseases …

Motivation The elucidation of dysfunctional cellular processes that can induce the onset of a
disease is a challenging issue from both the experimental and computational perspectives …

The ongoing cancer research has shown that malignant tumour cells have highly disrupted
signalling transduction pathways. In cancer cells, signalling pathways are altered to satisfy …

Despite recent increases in the cure rate of acute lymphoblastic leukemia (ALL), adult ALL
remains a high-risk disease that exhibits a high relapse rate. In this study, we found that the …