The regulation of fear memories is critical for adaptive behaviors and dysregulation of these processes is implicated in trauma-and stress-related disorders. Treatments for these …
M Barad - Current opinion in neurobiology, 2005 - Elsevier
Fear extinction, the reduction of fear by repeated exposure to the object of fear, is a crucial paradigm of inhibitory learning and the acknowledged preclinical model for behavior …
KA Corcoran, GJ Quirk - CNS spectrums, 2007 - cambridge.org
Anxiety disorders are commonly treated with exposure-based therapies that rely on extinction of conditioned fear. Persistent fear and anxiety following exposure therapy could …
The ability to extinguish conditioned fear memory is critical for adaptive control of fear response, and its impairment is a hallmark of emotional disorders like post-traumatic stress …
Fear extinction is a form of inhibitory learning that allows for the adaptive control of conditioned fear responses. Although fear extinction is an active learning process that …
Persistent anxiety after a psychological trauma is a hallmark of many anxiety disorders. However, the neural circuits mediating the extinction of traumatic fear memories remain …
Understanding how fears are acquired is an important step in translating basic research to the treatment of fear-related disorders. However, understanding how learned fears are …
D Mueller, JT Porter, GJ Quirk - Journal of neuroscience, 2008 - Soc Neuroscience
Emotional arousal strengthens memory. This is most apparent in aversive conditioning, in which the stress-related neurotransmitter norepinephrine (NE) enhances associations …
JM Stafford, DAK Maughan, EC Ilioi… - Learning & …, 2013 - learnmem.cshlp.org
An issue of increasing theoretical and translational importance is to understand the conditions under which learned fear can be suppressed, or even eliminated. Basic research …