The etiology of multiple sclerosis (MS) is not clear, and the treatment of MS presents a great
challenge. This study aimed to investigate the pathogenesis and potential therapeutic …

Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis
(EAE), are autoimmune diseases characterized by immune-mediated neuroinflammation …

Oligodendrocyte (OL) death and remyelination failure lead to progressive neurological
deficits in multiple sclerosis (MS) and its animal model, experimental autoimmune …

Experimental autoimmune encephalomyelitis (EAE) is a classical experimental model of
multiple sclerosis (MS), an autoimmune disease of the central nervous system (CNS) …

Multiple sclerosis (MS) is a debilitating, inflammatory, and demyelinating disease of the
central nervous system influenced by environmental and genetic factors. Around 2.8 million …

Aims Matrine (MAT), a quinolizidine alkaloid derived from the herb Radix Sophorae
flavescens, has been recently found to be beneficial in experimental autoimmune …

Matrine (MAT), a quinolizidine alkaloid component derived from the root of Sophora
flavescens, suppresses experimental autoimmune encephalomyelitis (EAE), the animal …

Abstract Inflammation, demyelination, oligodendrocyte (OLG) death, and axonal
degeneration are primary characteristics of multiple sclerosis (MS) and its animal model …

Objective and design Multiple sclerosis (MS) is a debilitating autoimmune disease involving
immune dysregulation of the pathogenic T helper 17 (Th17) versus protective T regulatory …

Astrocytes (AST) play an important role in the pathogenesis of neurological disorders, and
their activation is involved in the progression of multiple sclerosis (MS).(6aS, 10S, 11aR …