Introduction: Transporters and enzymes play an important role in absorption, distribution,
clearance and elimination of drugs. Areas covered: This review provides an overview of the …

Introduction: Membrane transporters have been recognized to play a key role in determining
the absorption, distribution and elimination processes of drugs. The organic anion …

Background: Hepatic transporters, including efflux transporters and uptake transporters,
have been recognized to play an important role in the disposition of various drugs. These …

The hypothesis that cytochrome P450 3A (CYP3A) and P-glycoprotein (P-gp) played
complementary roles in drug absorption and disposition was first proposed 15 years ago. 1 …

A large body of evidence suggests hepatic uptake transporters, organic anion‐transporting
polypeptides (OATPs), are of high clinical relevance in determining the pharmacokinetics of …

Hepatobiliary transport mechanisms have been identified to play a significant role in
determining the systemic clearance for a number of widely prescribed drugs and an …

Over the years, there has been an increase in the number and quality of available in vitro
tools for the assessment of clearance. Complexity of data analysis and modelling of …

Transporter‐mediated drug–drug interactions are one of the major mechanisms in
pharmacokinetic‐based drug interactions and correspondingly affecting drugs' safety and …

Membrane transporters play an important role in the absorption, distribution, clearance, and
elimination of drugs. Supported by the pharmacokinetics data in human, several transporters …

The ability to predict hepatic metabolic clearance is a key component in the design and
selection of small molecule drug candidates within the pharmaceutical industry. The …