The papain-like protease (PLpro) found in coronaviruses that can be transmitted from
animals to humans is a critical target in respiratory diseases linked to Severe Acute …

The papain-like protease (PLpro) from zoonotic coronaviruses (CoVs) has been identified as
a target with an essential role in viral respiratory diseases caused by Severe Acute …

ABSTRACT SARS-CoV-2 PLpro was investigated as a therapeutic target for potent antiviral
drugs due to its essential role in not only viral replication but also in regulating the inborn …

Abstract SARS-CoV-2 papain-like protease (PLpro), a key viral protease, plays a crucial role
in the viral replication and pathogenesis, making it an attractive target for the development of …

The worldwide COVID-19 pandemic caused by the coronavirus SARS-CoV-2 urgently
demands novel direct antiviral treatments. The main protease (Mpro) and papain-like …

The development of inhibitors that target the papain‐like protease (PLpro) has the potential
to counteract the spread of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV …

The current ongoing pandemic of COVID-19 urges immediate treatment measures for
controlling the highly contagious SARS-CoV-2 infections. The papain-like protease (PLpro) …

Global public health has been a critical problem by the sudden increase of the COVID-19
outbreak. The papain-like protease (PLpro) of SARS-CoV-2 is a key promising target for …

The rapid global spread of the SARS-CoV-2 virus facilitated the development of novel direct-
acting antiviral agents (DAAs). The papain-like protease (PLpro) has been proposed as one …

This study explores the repurposing of Food and Drug Administration (FDA)-approved drugs
as potential inhibitors of SARS-CoV-2 papain-like protease (PLpro), a critical enzyme for …