There is an expanding role for interleukin (IL)-1 in diseases from gout to cancer. More than
any other cytokine family, the IL-1 family is closely linked to innate inflammatory and immune …

Gout is the most common inflammatory arthritis in humans. Current treatment options to
control the pain and inflammation of acute and chronic gout include nonsteroidal anti …

Interleukin‐1 (IL‐1) inhibitors potentially have a role as antiinflammatory agents in refractory
gout or for patients who are unable to tolerate conventional therapy, such as nonsteroidal …

DISCUSSION Due to the patient's comorbidities and intolerance to standard medications, an
unconventional treatment strategy for gout was required. Oxypurinol was considered but …

The inflammatory cytokines IL-1α and IL-1β orchestrate local and systemic inflammatory
responses underlying a broad spectrum of diseases. Three agents for reducing IL-1 …

Inflammation is an essential process in response to injury and infection. However, under
certain circumstances dis‐regulation of this process can lead to pathologies such as …

This issue of Seminars in Immunology on The Interleukin-1 (IL-1) Family of Ligands and
Receptors updates the rapidly expanding importance of this family. There are individual …

Cytokine‐driven inflammation and tissue destruction is a common theme of chronic
inflammatory diseases such as rheumatoid arthritis, Crohn's disease, ulcerative colitis …

Introduction: Gout is a painful inflammatory arthritis with a prevalence of approximately 4% in
the United States, affecting an estimated 8.3 million adults. The past 20 years have shown …

The potent pro-inflammatory actions of members of the interleukin (IL)-6 cytokine and toll-
like receptor (TLR) families have been implicated in numerous inflammatory disorders, as …