Clinical utility of lipoprotein (a) and LPA genetic risk score in risk prediction of incident atherosclerotic cardiovascular disease
Importance Lipoprotein (a) is a highly heritable biomarker independently associated with
atherosclerotic cardiovascular disease (ASCVD). It is unclear whether measured lipoprotein …
atherosclerotic cardiovascular disease (ASCVD). It is unclear whether measured lipoprotein …
Ancestry, Lipoprotein(a), and Cardiovascular Risk Thresholds: JACC Review Topic of the Week
S Tsimikas, SM Marcovina - Journal of the American College of Cardiology, 2022 - jacc.org
This study reviews ancestral differences in the genetics of the LPA gene, risk categories of
elevated lipoprotein (a)[Lp (a)] as defined by guidelines, ancestry-specific Lp (a) risk …
elevated lipoprotein (a)[Lp (a)] as defined by guidelines, ancestry-specific Lp (a) risk …
Association of LPA variants with risk of coronary disease and the implications for lipoprotein (a)-lowering therapies: a Mendelian randomization analysis
Importance Human genetic studies have indicated that plasma lipoprotein (a)(Lp [a]) is
causally associated with the risk of coronary heart disease (CHD), but randomized trials of …
causally associated with the risk of coronary heart disease (CHD), but randomized trials of …
Phenotypic characterization of genetically lowered human lipoprotein (a) levels
Background: Genomic analyses have suggested that the LPA gene and its associated
plasma biomarker, lipoprotein (a)(Lp [a]), represent a causal risk factor for coronary heart …
plasma biomarker, lipoprotein (a)(Lp [a]), represent a causal risk factor for coronary heart …
Lipoprotein (a) and family history predict cardiovascular disease risk
Abstract Background Elevated lipoprotein (a)(Lp [a]) and family history (FHx) of coronary
heart disease (CHD) are individually associated with cardiovascular risk, and Lp (a) is …
heart disease (CHD) are individually associated with cardiovascular risk, and Lp (a) is …
[HTML][HTML] Ideal cardiovascular health influences cardiovascular disease risk associated with high lipoprotein (a) levels and genotype: the EPIC-Norfolk prospective …
N Perrot, R Verbeek, M Sandhu, SM Boekholdt… - Atherosclerosis, 2017 - Elsevier
Background and aims Lipoprotein (a)(Lp [a]) is a strong genetic risk factor for cardiovascular
disease (CVD). The American Heart Association has prioritised seven cardiovascular health …
disease (CVD). The American Heart Association has prioritised seven cardiovascular health …
A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms [S]
High lipoprotein (a)[Lp (a)] concentrations are an independent risk factor for cardiovascular
outcomes. Concentrations are strongly influenced by apo (a) kringle IV repeat isoforms. We …
outcomes. Concentrations are strongly influenced by apo (a) kringle IV repeat isoforms. We …
Genome-Wide Association Study and Identification of a Protective Missense Variant on Lipoprotein (a) Concentration: Protective Missense Variant on Lipoprotein (a) …
MA Said, MW Yeung, YJ van de Vegte… - … , and vascular biology, 2021 - Am Heart Assoc
Objective: Lipoprotein (a)(Lp [a]) is associated with coronary artery disease (CAD) but also
to LDL (low-density lipoprotein) cholesterol. The genetic architecture of Lp (a) remains …
to LDL (low-density lipoprotein) cholesterol. The genetic architecture of Lp (a) remains …
Genome-Wide Association Study Highlights APOH as a Novel Locus for Lipoprotein(a) Levels—Brief Report
M Hoekstra, HY Chen, J Rong, L Dufresne… - … , and vascular biology, 2021 - Am Heart Assoc
Objective: Lp (a)(lipoprotein [a]) is an independent risk factor for cardiovascular diseases
and plasma levels are primarily determined by variation at the LPA locus. We performed a …
and plasma levels are primarily determined by variation at the LPA locus. We performed a …
Lipoprotein (a) and major adverse cardiovascular events in patients with or without baseline atherosclerotic cardiovascular disease
Abstract Background Lipoprotein (a)[Lp (a)] is associated with an increased risk of
atherosclerotic cardiovascular disease (ASCVD). However, whether the optimal Lp (a) …
atherosclerotic cardiovascular disease (ASCVD). However, whether the optimal Lp (a) …