The biological predisposition to obesity: beyond the thrifty genotype scenario

C Bouchard - International journal of obesity, 2007 - nature.com
It is hard to dispute the fact that the prevalence of overweight and obesity is increasing
around the world and that the obese are becoming more severely obese. However, there …

Evolutionary perspectives on the obesity epidemic: adaptive, maladaptive, and neutral viewpoints

JR Speakman - Annual review of nutrition, 2013 - annualreviews.org
The prevalence of obesity in modern societies has two major contributory factors—an
environmental change that has happened in historical times and a genetic predisposition …

On the evolutionary origins of obesity: a new hypothesis

D Sellayah, FR Cagampang, RD Cox - Endocrinology, 2014 - academic.oup.com
Obesity is an escalating threat of pandemic proportions, currently affecting billions of people
worldwide and exerting a devastating socioeconomic influence in industrialized countries …

[图书][B] Obesity: genomics and postgenomics

K Clément, TIA Sorensen - 2007 - books.google.com
This book comprehensively accounts the current understanding of genetic mechanisms of
obesity by analyzing obesity phenotypes and genotypes and, gene polymorphisms and …

Revisiting the evolutionary origins of obesity: lazy versus peppy‐thrifty genotype hypothesis

H Reddon, Y Patel, M Turcotte, M Pigeyre… - Obesity …, 2018 - Wiley Online Library
The recent global obesity epidemic is attributed to major societal and environmental
changes, such as excessive energy intake and sedentary lifestyle. However, exposure to …

Recent advances in obesity: genetics and beyond

WW Cheung, P Mao - International Scholarly Research Notices, 2012 - Wiley Online Library
The prevalence of obesity, which is a heritable trait that arises from the interactions of
multiple genes and lifestyle factors, continues to increase worldwide, causing serious health …

Current review of genetics of human obesity: from molecular mechanisms to an evolutionary perspective

D Albuquerque, E Stice, R Rodríguez-López… - Molecular genetics and …, 2015 - Springer
It is well-known that obesity is a complex multifactorial and heterogeneous condition with an
important genetic component. Recently, major advances in obesity research emerged …

On the origin of obesity: identifying the biological, environmental and cultural drivers of genetic risk among human populations

A Qasim, M Turcotte, RJ de Souza… - Obesity …, 2018 - Wiley Online Library
Genetic predisposition to obesity presents a paradox: how do genetic variants with a
detrimental impact on human health persist through evolutionary time? Numerous …

The genetics of human obesity

Q Xia, SFA Grant - Annals of the New York Academy of …, 2013 - Wiley Online Library
It has long been known that there is a genetic component to obesity, and that characterizing
this underlying factor would likely offer the possibility of better intervention in the future …

Genetics and common obesities: background, current status, strategies, and future prospects.

RA Price - 2002 - cabidigitallibrary.org
This chapter first reviews what we know about the inheritance of human obesity; it then
discusses methodological obstacles, current status, strategies, and future prospects for …