OBJECTIVE: Hypercortisolaemia has been well described in depression and may be a
factor associated with treatment resistance. The role of the more abundant adrenal steroid …

We read with interest the study by Young and colleagues (2001). The authors report the
results of a study in which plasma cortisol and ACTH were sampled at 10-minute intervals …

OBJECTIVE: Elevated basal cortisol levels are a feature of depressive illness and cause
deficits in learning and memory. The adrenal steroid dehydroepiandrosterone (DHEA) has …

Background Major depressive disorder (MDD) has been associated with low
dehydroepiandrosterone-sulphate (DHEAS),–particularly relative to high cortisol–although …

Hypercortisolaemia is a feature of many severe psychiatric illnesses and has been
suggested to be both a causal and exacerbating factor of clinical symptoms and …

BACKGROUND: Dehydroepiandrosterone (DHEA) and its sulphate form (DHEA) are
neuroactive steroids with antiglucocorticoid properties. An imbalance in the ratio of cortisol …

OBJECTIVE: Clinical studies of endogenous concentrations of dehydroepiandrosterone
(DHEA) and its relation to depression are limited. This study examined whether pre-and post …

Activation of the hypothalamus-pituitary-adrenocortical system is a biological core symptom
of depression. Although the regulation of cortisol secretion is well studied in this condition …

Objective: Patients with major depression frequently have high Cortisol levels and
resistance to dexamethasone. We sought to determine to what extent major depression …

DHEA is marketed and readily available as a daily nutritional supplement to counteract the
effects of aging. The effect of DHEA administration on 24-hour plasma cortisol profiles has …