Cardiovascular disease, a primary cause of mortality in the United States, has a complex
pathologic process involving many genes. The high-throughput technology (microarray or" …

Study Objectives Effective use of microarray experiments requires clear objectives and
effective study design. Clearly stated study objectives are needed to determine the …

Background: to date, only three groups have reported data from large scale genetic
association studies of coronary heart disease using a case control design. Methods and …

Cardiovascular disease is the most important cause of morbidity and mortality in developed
countries, causing twice as many deaths as cancer in the USA. The major cardiovascular …

A paradigm shift toward biology occurred in the 1990s and was subsequently catalyzed by
the sequencing of the human genome in 2000. The cost of deoxyribonucleic acid (DNA) …

Discovery of genetic risk variants for CAD and their assembly on a computerized microarray
enables a genetic risk score (GRS) to be expressed as a single number. Utilizing this array …

The application of genomics technology to clinical cardiovascular research is producing
fundamentally new insights concerning the etiology of cardiovascular disease phenotypes …

Although the contribution of genetics to complex cardiovascular diseases such as
atherosclerosis has been accepted for quite some time, full and detailed knowledge of the …

The evidence that genetic factors are of importance in the etiology of coronary heart disease
(CHD) originates from several areas. Cases of premature CHD cluster in families in a way …

The development of atherosclerotic disease is a complex process, involving interactions
among immune cells and cytokines, lipids and lipoproteins, blood coagulant and fibrinolytic …