The human genome is predominantly composed of nonprotein-coding sequences whose
function remains largely undefined. A significant portion of the noncoding DNA is believed to …

Genetic interactions influence many phenotypes and can be used as a powerful
experimental tool to discover functional relationships between genes. Here we describe a …

DNase I hypersensitive sites (DHSs) provide important information on the presence of
transcriptional regulatory elements and the state of chromatin in mammalian cells …

The architecture of chromatin regulates eukaryotic cell states by controlling transcription
factor access to sites of gene regulation. Here we describe a dual transposase–peroxidase …

A major challenge in cancer genomics is uncovering genes with an active role in
tumorigenesis from a potentially large pool of mutated genes across patient samples. Here …

The human genome encodes the blueprint of life, but the function of the vast majority of its
nearly three billion bases is unknown. The Encyclopedia of DNA Elements (ENCODE) …

The human genome encodes the blueprint of life, but the function of the vast majority of its
nearly three billion bases is unknown. The Encyclopedia of DNA Elements (ENCODE) …

A transcriptional regulatory network represents a molecular framework in which
developmental or environmental cues are transformed into differential expression of genes …

Abstract'Epigenome'refers to the panoply of chemical modifications borne by DNA and its
associated proteins that locally affect genome function. Epigenomic patterns are thought to …

Transcription factors (TFs) that bind common DNA motifs in vitro occupy distinct sets of
promoters in vivo, raising the question of how binding specificity is achieved. TFs are …