Li et al 1 recently reported the association between risk of 22 cancers and BRCA1 and
BRCA2 pathogenic variants (PVs) in the Consortium of Investigators of Modifiers of the …

Purpose Whereas lung cancer incidence among men has declined in recent years, the
incidence rate among women has increased rapidly. Sex could affect DNA repair capacity …

Abstract Introduction BRCA1 and BRCA2 (BReast CAncer susceptibility genes) are two
tumor-suppressor genes associated with the hereditary breast and ovarian cancer …

Deleterious BRCA2 genetic variants markedly increase risk of developing breast cancer. A
rare truncating BRCA2 genetic variant, rs11571833 (K3326X), has been associated with a …

Background Most pathogenic mutations in the BRCA2 gene carry a high risk of hereditary
breast and ovarian cancer (HBOC). However, a stop-gain mutation, K3326*(rs11571833) …

PURPOSE To provide precise age-specific risk estimates of cancers other than female
breast and ovarian cancers associated with pathogenic variants (PVs) in BRCA1 and …

The recent analysis of penetrance obtained from high-risk families in North America gives
rise to some concern, as it purports to provide useful information to women undertaking …

Background and objective: BRCA1 and BRCA2 are associated with many cancer types in
addition to hereditary breast and ovarian cancers. However, their relation to lung cancer …

Importance The limited data on cancer phenotypes in men with germlineBRCA1 and
BRCA2pathogenic variants (PVs) have hampered the development of evidence-based …

Breast and lung cancer are two of the most common malignancies in the United States,
causing approximately 40,000 and 160,000 deaths each year, respectively. Over 80% of …