Background Despite the frequent use of self-controlled methods in
pharmacoepidemiological studies, the factors that may bias the estimates from these …

Background Observational studies are widely used in pharmacoepidemiology. Several
designs can be used, in particular self-controlled designs (case-crossover and self …

Purpose The assumption that the occurrence of outcome event must not alter subsequent
exposure probability is critical for preserving the validity of the self‐controlled case series …

Self-controlled study designs, also known as case-only designs or Self-controlled Crossover
Observational PharmacoEpidemiologic (SCOPE) studies, include case-crossover (CCO) …

Purpose Consensus is needed on conceptual foundations, terminology and relationships
among the various self‐controlled “trigger” study designs that control for time‐invariant …

For self-controlled studies of medication-related effects, time-varying confounding by
indication can occur if the indication varies over time. We describe how active comparators …

Background The self-controlled case series (SCCS) offers potential as an statistical method
for risk identification involving medical products from large-scale observational healthcare …

Background Case-only designs have been used since late 1980's. In these, as opposed to
case-control or cohort studies for instance, only cases are required and are self-controlled …

Self-Controlled Case Series Studies: A Modelling Guide with R provides the first
comprehensive account of the self-controlled case series (SCCS) method, a statistical …

Self-matched case-only studies (such as the case-crossover or self-controlled case-series
method) control by design for time-invariant confounders (measured or unmeasured), but …